1 Ocak 2024 Dergi makalesi Açık Erişim

Ishimoto, Tatsushi; Arakawa, Yukiyasu; Vural, Secil; Stoehr, Julia; Vollmer, Sigrid; Galinski, Adrian; Siewert, Katherina; Ruehl, Geraldine; Poluektov, Yuri; Delcommenne, Marc; Horvath, Orsolya; He, Mengwen; Summer, Burkhard; Pohl, Ralf; Alharbi, Rehab; Dornmair, Klaus; Arakawa, Akiko; Prinz, Joerg C.

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    <subfield code="a">&lt;p&gt;Introduction: Psoriasis is a T-cell mediated autoimmune skin disease. HLA-C*06:02 is the main psoriasis-specific risk gene. Using a V alpha 3S1/V beta 13S1 T-cell receptor (TCR) from a lesional psoriatic CD8(+) T-cell clone we had discovered that, as an underlying pathomechanism, HLA-C*06:02 mediates an autoimmune response against melanocytes in psoriasis, and we had identified an epitope from ADAMTS-like protein 5 (ADAMTSL5) as a melanocyte autoantigen. The conditions activating the psoriatic autoimmune response in genetically predisposed individuals throughout life remain incompletely understood. Here, we aimed to identify environmental antigens that might trigger autoimmunity in psoriasis because of TCR polyspecificity. Methods: We screened databases with the peptide recognition motif of the V alpha 3S1/V beta 13S1 TCR for environmental proteins containing peptides activating this TCR. We investigated the immunogenicity of these peptides for psoriasis patients and healthy controls by lymphocyte stimulation experiments and peptide-loaded HLA-C*06:02 tetramers. Results: We identified peptides from wheat, Saccharomyces cerevisiae, microbiota, tobacco, and pathogens that activated both the V alpha 3S1/V beta 13S1 TCR and CD8(+) T cells from psoriasis patients. Using fluorescent HLA-C*06:02 tetramers loaded with ADAMTSL5 or wheat peptides, we find that the same CD8(+) T cells may recognize both autoantigen and environmental antigens. A wheat-free diet could alleviate psoriasis in several patients. Discussion: Our results show that due to TCR polyspecificity, several environmental antigens corresponding to previously suspected psoriasis risk conditions converge in the reactivity of a pathogenic psoriatic TCR and might thus be able to stimulate the psoriatic autoimmune response against melanocytes. Avoiding the corresponding environmental risk factors could contribute to the management of psoriasis.&lt;/p&gt;</subfield>
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    <subfield code="a">Ishimoto, Tatsushi</subfield>
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    <subfield code="a">10.3389/fimmu.2024.1374581</subfield>
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    <subfield code="a">Multiple environmental antigens may trigger autoimmunity in psoriasis through T-cell receptor polyspecificity</subfield>
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    <subfield code="a">Stoehr, Julia</subfield>
    <subfield code="u">Ludwig Maximilian Univ Munich, Univ Hosp, Dept Dermatol &amp; Allergy, Munich, Germany</subfield>
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    <subfield code="a">Vollmer, Sigrid</subfield>
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    <subfield code="a">Galinski, Adrian</subfield>
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    <subfield code="a">Arakawa, Akiko</subfield>
    <subfield code="u">Ludwig Maximilian Univ Munich, Univ Hosp, Dept Dermatol &amp; Allergy, Munich, Germany</subfield>
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    <subfield code="a">Prinz, Joerg C.</subfield>
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