1 Ocak 2024 Dergi makalesi Açık Erişim

Polat, Muhammed Fatih; Durmaz Sahin, Irem; Atalay, Rengul; Tuncbilek, Meral

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/281027</identifier>
  <creators>
    <creator>
      <creatorName>Polat, Muhammed Fatih</creatorName>
      <givenName>Muhammed Fatih</givenName>
      <familyName>Polat</familyName>
      <affiliation>Erzincan Binali Yildirim Univ, Fac Pharm, Dept Pharmaceut Basic Sci, Erzincan, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Durmaz Sahin, Irem</creatorName>
      <givenName>Irem</givenName>
      <familyName>Durmaz Sahin</familyName>
    </creator>
    <creator>
      <creatorName>Atalay, Rengul</creatorName>
      <givenName>Rengul</givenName>
      <familyName>Atalay</familyName>
    </creator>
    <creator>
      <creatorName>Tuncbilek, Meral</creatorName>
      <givenName>Meral</givenName>
      <familyName>Tuncbilek</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, Ankara, Turkiye</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Exploration Of Novel 6,8,9-Trisubstituted Purine Analogues: Synthesis, In Vitro Biological Evaluation, And Their Effect On Human Cancer Cells</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2024</publicationYear>
  <dates>
    <date dateType="Issued">2024-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/281027</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.55730/1300-0527.3643</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Cancer, a leading global cause of mortality, demands continuous advancements in therapeutic strategies. This study focuses on the design and synthesis of a novel series of purine derivatives, specifically 6 -(substituted phenyl piperazine)-8-(4-phenoxyphenyl)9-cyclopentyl purine derivatives (5-11). The motivation behind this endeavor lies in addressing acquired resistance mechanisms in cancer cells, a significant hurdle in current treatment modalities. The synthesis, starting from 4,6-dichloro-5-nitropyrimidine, involves a multi -step process, resulting in seven new purine derivatives. Biological evaluation against human liver, colon, and breast cancer cells (Huh7, HCT116, and MCF7, respectively) was performed using the SRB assay. Among the synthesized analogs, compounds 5 and 6, exhibited notable cytotoxic activity, surpassing clinically used positive controls 5-Fluorouracil and Fludarabine in terms of efficacy. This research underscores the potential of purine derivatives with a phenyl group at the C-8 position as a scaffold for developing compounds with improved anticancer properties. The findings offer insights for future exploration and development of novel agents in cancer pharmaceutical research.&lt;/p&gt;</description>
  </descriptions>
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