1 Ocak 2024 Dergi makalesi Açık Erişim

Bal-Ozturk, Ayca; Torkay, Gulsah; Idil, Neslihan; Akar, Remzi Okan; Ozbas, Zehra; Ozkahraman, Bengi

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
    <subfield code="o">oai:aperta.ulakbim.gov.tr:280001</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;The ultimate goal of this study was to establish the groundwork for the development of high-mechanical pullulan based films for wound healing applications. For this purpose, pullulan (PUL) was successfully methacrylated with different methacrylic anhydride amounts and used for the fabrication of photocurable wound dressing films (PULMA). The mechanical properties of the films, evaluated by changing the methacrylation degree and polymer concentration for better mechanical performance, indicated the best results in terms of elastic modulus (2.55 +/- 0.15 MPa), tensile strength (2.48 +/- 0.12 MPa), and elongation at break (848 +/- 111 %). Additionally, the incorporation of PRO into wound dressing films has demonstrated strong antibacterial activity against Escherichia coli and Staphylococcus aureus, and it has also improved the release profile. The obtained films have scavenging properties against 2,2-diphenyl-1-picrylhydrazyl (DPPH). The wound dressing films were not cytotoxic to NIH/ 3T3 cells, a fibroblast cell line, according to the cytotoxicity assay. The in vitro scratch test showed that PRO incorporated films induced cell migration, suggesting that they have the potential to close wounds and promote healing. According to the image analysis conducted following the in ovo chorioallantoic membrane (CAM) test, PRO inclusion boosted different angiogenesis parameters stemming from the films. Clear evidence has been found that PRO loaded into high mechanical performance PUL based films can be suitable for advanced wound dressing applications.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Bal-Ozturk, Ayca</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:43b148950974db1a22ba1e87580ab94c</subfield>
    <subfield code="s">317</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/280001/files/bib-38a888cd-2573-49fd-8342-8e99efec592e.txt</subfield>
  </datafield>
  <controlfield tag="005">20250417205431.0</controlfield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2024-01-01</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1016/j.ijbiomac.2024.137071</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Propolis-loaded photocurable methacrylated pullulan films: Evaluation of mechanical, antibacterial, biocompatibility, wound healing and pro-angiogenic abilities</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="v">282</subfield>
    <subfield code="c">14</subfield>
    <subfield code="p">INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Torkay, Gulsah</subfield>
    <subfield code="u">Istinye Univ, Inst Hlth Sci, Dept Stem Cell &amp; Tissue Engn, TR-34010 Istanbul, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Idil, Neslihan</subfield>
    <subfield code="u">Hacettepe Univ, Fac Sci, Dept Biol, TR-06800 Ankara, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Akar, Remzi Okan</subfield>
    <subfield code="u">Istinye Univ, Dept Clin Biochem, Med Sch, TR-34010 Istanbul, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ozbas, Zehra</subfield>
    <subfield code="u">Cankiri Karatekin Univ, Fac Engn, Chem Engn Dept, TR-18100 Cankiri, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ozkahraman, Bengi</subfield>
    <subfield code="u">Hitit Univ, Fac Engn, Polymer Mat Engn Dept, TR-19030 Corum, Turkiye</subfield>
  </datafield>
  <controlfield tag="001">280001</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
</record>