1 Ocak 2025 Dergi makalesi Açık Erişim

Koc, Cansu; Aydemir, Cigdem Inci; Salman, Berna; Cakir, Aysen; Akbulut, Nursel Hasanoglu; Karabarut, Pinar Levent; Topal, Gonca; Cinar, Aycan Yigit; Taner, Gokce; Eyigor, Ozhan; Cansev, Mehmet

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/279715</identifier>
  <creators>
    <creator>
      <creatorName>Koc, Cansu</creatorName>
      <givenName>Cansu</givenName>
      <familyName>Koc</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Pharmacol, TR-16059 Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Aydemir, Cigdem Inci</creatorName>
      <givenName>Cigdem Inci</givenName>
      <familyName>Aydemir</familyName>
      <affiliation>Bursa Tech Univ, Grad Educ Inst, Dept Biotechnol, Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Salman, Berna</creatorName>
      <givenName>Berna</givenName>
      <familyName>Salman</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Pharmacol, TR-16059 Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Cakir, Aysen</creatorName>
      <givenName>Aysen</givenName>
      <familyName>Cakir</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Physiol, Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Akbulut, Nursel Hasanoglu</creatorName>
      <givenName>Nursel Hasanoglu</givenName>
      <familyName>Akbulut</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Histol &amp; Embryol, Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Karabarut, Pinar Levent</creatorName>
      <givenName>Pinar Levent</givenName>
      <familyName>Karabarut</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Pharmacol, TR-16059 Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Topal, Gonca</creatorName>
      <givenName>Gonca</givenName>
      <familyName>Topal</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Histol &amp; Embryol, Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Cinar, Aycan Yigit</creatorName>
      <givenName>Aycan Yigit</givenName>
      <familyName>Cinar</familyName>
      <affiliation>Bursa Tech Univ, Fac Engn &amp; Nat Sci, Dept Food Engn, Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Taner, Gokce</creatorName>
      <givenName>Gokce</givenName>
      <familyName>Taner</familyName>
      <affiliation>Bursa Tech Univ, Fac Engn &amp; Nat Sci, Dept Bioengn, Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Eyigor, Ozhan</creatorName>
      <givenName>Ozhan</givenName>
      <familyName>Eyigor</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Histol &amp; Embryol, Bursa, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Cansev, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Cansev</familyName>
      <affiliation>Bursa Uludag Univ, Fac Med, Dept Pharmacol, TR-16059 Bursa, Turkiye</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Comparative Neuroprotective Effects Of Royal Jelly And Its Unique Compound 10-Hydroxy-2-Decenoic Acid On Ischemia-Induced Inflammatory, Apoptotic, Epigenetic And Genotoxic Changes In A Rat Model Of Ischemic Stroke</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2025</publicationYear>
  <dates>
    <date dateType="Issued">2025-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/279715</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1080/1028415X.2024.2344141</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;ObjectivesThis study aimed to compare the efficacy of royal jelly (RJ) and its major fatty acid 10-hydroxy-2-decenoic acid (10-HDA) on ischemic stroke-related pathologies using histological and molecular approaches.MethodsMale rats were subjected to middle cerebral artery occlusion (MCAo) to induce ischemic stroke and were supplemented daily with either vehicle (control group), RJ or 10-HDA for 7 days starting on the day of surgery. On the eighth day, rats were sacrificed and brain tissue and blood samples were obtained to analyze brain infarct volume, DNA damage as well as apoptotic, inflammatory and epigenetic parameters.ResultsBoth RJ and 10-HDA supplementation significantly reduced brain infarction and decreased weight loss when compared to control animals. These effects were associated with reduced levels of active caspase-3 and PARP-1 and increased levels of acetyl-histone H3 and H4. Although both RJ and 10-HDA treatments significantly increased acetyl-histone H3 levels, the effect of RJ was more potent than that of 10-HDA. RJ and 10-HDA supplementation also alleviated DNA damage by significantly reducing tail length, tail intensity and tail moment in brain tissue and peripheral lymphocytes, except for the RJ treatment which tended to reduce tail moment in lymphocytes without statistical significance.ConclusionsOur findings suggest that neuroprotective effects of RJ in experimental stroke can mostly be attributed to 10-HDA.&lt;/p&gt;</description>
  </descriptions>
</resource>