1 Ocak 2025 Dergi makalesi Açık Erişim

Aydin, Bilge; Alkuyruk, Satuk Bugra; Tekman, Enes; Yuca, Hafize; Karadayi, Mehmet; Gulsahin, Yusuf; Cecen, Oemer; Bona, Gulnur Eksi; Demirci, Betul; Bona, Mehmet; Karakaya, Songul

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
    <subfield code="o">oai:aperta.ulakbim.gov.tr:278275</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Cyclotrichium origanifolium, a plant widely used in Eastern and Southern Anatolia for culinary purposes, was subject of this study, which aimed to comprehensively evaluate its potential therapeutic applications. This research stands out due to its holistic approach, combining morpho-anatomical studies, chemical, and biological analyses to explore antioxidant, antidiabetic, anticholinesterase, genotoxic, and anti-genotoxic effects of methanolic and aqueous extracts, as well as flowering aerial part essential oil. It is a perennial plant, typically ranging from 10 to 40 cm in height, with a suffrutescent and highly branched growth habit. Essential oils are produced within glandular trichomes. Oil, analyzed via GC-MS/MS, revealed 24 compounds accounting for 96.4% of oil, with isomenthone (52.4%), pulegone (23.4%), and beta-pinene (9.5%) as predominant components. These findings are significant as they provide new insights into chemical composition of oils, particularly highlighting pharmacologically active compounds. Methanol extract exhibited superior antioxidant activity, correlated with high phenol and tannin content. Essential oil showed moderate inhibition of alpha-amylase (49.54%) and mild inhibition of acetylcholinesterase (11.84%) and butyrylcholinesterase (16.93%), suggesting potential in managing oxidative stress and neurodegenerative diseases. Study also conducted biosafety evaluations using Ames/Salmonella and Allium tests, essential for assessing genotoxic and antigenotoxic potential of natural products. Notably, significant antimicrobial effects were identified, particularly against Pseudomonas aeruginosa and Enterococcus faecalis. Comprehensive analysis and discovery of significant bioactivities position this research as a valuable contribution to field, distinguishing it from previous studies on similar species. This study provides a foundational understanding of morpho-anatomical, pharmacological, biological properties of plant, opening avenues for future research.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Aydin, Bilge</subfield>
    <subfield code="u">Erzincan Binali Yildirim Univ, Dept Pharmacognosy, Erzincan, Turkiye</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:49694e729399da50260913034e294912</subfield>
    <subfield code="s">374</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/278275/files/bib-239c6129-c7fb-422b-980a-f1c14ffbe525.txt</subfield>
  </datafield>
  <controlfield tag="005">20250417182854.0</controlfield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2025-01-01</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1007/s00709-024-01992-5</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Investigating the phytochemical profile, biological potentials, morphological, and anatomical characteristics of &lt;i&gt;Cyclotrichium origanifolium&lt;/i&gt; (Labill.) Manden. &amp; Scheng. (Lamiaceae) from Turkey</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="v">262</subfield>
    <subfield code="p">PROTOPLASMA</subfield>
    <subfield code="c">20</subfield>
    <subfield code="n">2</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Alkuyruk, Satuk Bugra</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Tekman, Enes</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Yuca, Hafize</subfield>
    <subfield code="u">Ataturk Univ, Dept Pharm, Erzurum, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Karadayi, Mehmet</subfield>
    <subfield code="u">Ataturk Univ, Dept Biol, Erzurum, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Gulsahin, Yusuf</subfield>
    <subfield code="u">Ataturk Univ, Dept Biol, Erzurum, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Cecen, Oemer</subfield>
    <subfield code="u">Karamanoglu Mehmetbey Univ, Dept Plant &amp; Anim Prod, Karaman, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Bona, Gulnur Eksi</subfield>
    <subfield code="u">Istanbul Cerrahpasa Univ, Dept Pharmaceut Bot, Istanbul, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Demirci, Betul</subfield>
    <subfield code="u">Anadolu Univ, Dept Pharmacognosy, Eskisehir, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Bona, Mehmet</subfield>
    <subfield code="u">Istanbul Univ, Dept Biol, Istanbul, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Karakaya, Songul</subfield>
    <subfield code="u">Ataturk Univ, Fac Pharm, Dept Pharmaceut Bot, Erzurum, Turkiye</subfield>
  </datafield>
  <controlfield tag="001">278275</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
</record>