1 Ocak 2023 Dergi makalesi Açık Erişim

Senol, Halil; Ozgun-Acar, Ozden; Dag, Aydan; Eken, Ahmet; Guner, Huseyin; Aykut, Zaliha Gamze; Topcu, Gulacti; Sen, Alaattin

Citation Style Language JSON

{
  "DOI": "10.1021/acs.jnatprod.2c00798", 
  "abstract": "<p>Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3 beta- pentacosanoate (OPCA) on a preclinical model of MS. First, OPCA was synthesized semisynthetically and characterized. Then, the mice with MOG35-55-induced experimental autoimmune/ allergic encephalomyelitis (EAE) were given OPCA along with a reference drug (FTY720). Biochemical, cellular, and molecular analyses were performed in serum and brain tissues to measure anti-inflammatory and neuroprotective responses. OPCA treat-ment protected EAE-induced changes in mouse brains maintaining blood-brain barrier integrity and preventing inflammation. Moreover, the protein and mRNA levels of MS-related genes such as HLD-DR1, CCL5, TNF-alpha, IL6, and TGFB1 were significantly reduced in OPCA-treated mouse brains. Notably, the expression of genes, including PLP, MBP, and MAG, involved in the development and structure of myelin was significantly elevated in OPCA-treated EAE. Furthermore, therapeutic OPCA effects included a substantial reduction in pro-inflammatory cytokines in the serum of treated EAE animals. Lastly, following OPCA treatment, the promoter regions for most inflammatory regulators were hypermethylated. These data support that OPCA is a valuable and appealing candidate for human MS treatment since OPCA not only normalizes the pro-and anti-inflammatory immunological bias but also stimulates remyelination in EAE.</p>", 
  "author": [
    {
      "family": "Senol", 
      "given": " Halil"
    }, 
    {
      "family": "Ozgun-Acar", 
      "given": " Ozden"
    }, 
    {
      "family": "Dag", 
      "given": " Aydan"
    }, 
    {
      "family": "Eken", 
      "given": " Ahmet"
    }, 
    {
      "family": "Guner", 
      "given": " Huseyin"
    }, 
    {
      "family": "Aykut", 
      "given": " Zaliha Gamze"
    }, 
    {
      "family": "Topcu", 
      "given": " Gulacti"
    }, 
    {
      "family": "Sen", 
      "given": " Alaattin"
    }
  ], 
  "container_title": "JOURNAL OF NATURAL PRODUCTS", 
  "id": "273276", 
  "issue": "1", 
  "issued": {
    "date-parts": [
      [
        2023, 
        1, 
        1
      ]
    ]
  }, 
  "page": "16", 
  "title": "Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3\u03b2-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent", 
  "type": "article-journal", 
  "volume": "86"
}