1 Ocak 2023 Dergi makalesi Açık Erişim

Hacioglu, Gulay; Cirrik, Selma; Yavuz, Berna Tezcan; Tomruk, Canberk; Keskin, Arif; Uzunoglu, Emel; Takir, Selcuk

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/272562</identifier>
  <creators>
    <creator>
      <creatorName>Hacioglu, Gulay</creatorName>
      <givenName>Gulay</givenName>
      <familyName>Hacioglu</familyName>
    </creator>
    <creator>
      <creatorName>Cirrik, Selma</creatorName>
      <givenName>Selma</givenName>
      <familyName>Cirrik</familyName>
      <affiliation>Ordu Univ, Med Fac, Dept Physiol, Ordu, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Yavuz, Berna Tezcan</creatorName>
      <givenName>Berna Tezcan</givenName>
      <familyName>Yavuz</familyName>
      <affiliation>Giresun Univ, Med Fac, Dept Histol &amp; Embryol, Giresun, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Tomruk, Canberk</creatorName>
      <givenName>Canberk</givenName>
      <familyName>Tomruk</familyName>
      <affiliation>Samsun Educ &amp; Res Hosp, Samsun, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Keskin, Arif</creatorName>
      <givenName>Arif</givenName>
      <familyName>Keskin</familyName>
      <affiliation>Giresun Univ, Expt Anim Res Ctr, Giresun, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Uzunoglu, Emel</creatorName>
      <givenName>Emel</givenName>
      <familyName>Uzunoglu</familyName>
      <affiliation>Giresun Univ, Med Fac, Dept Microbiol, Giresun, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Takir, Selcuk</creatorName>
      <givenName>Selcuk</givenName>
      <familyName>Takir</familyName>
      <affiliation>Giresun Univ, Med Fac, Dept Pharmacol, Giresun, Turkiye</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Bdnf-Trkb Signaling Pathway Is Partially Involved In The Neuroprotective Effects Of Hydrogen Sulfide In Parkinson'S Disease</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2023</publicationYear>
  <dates>
    <date dateType="Issued">2023-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/272562</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ejphar.2023.175595</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Recent studies have demonstrated that hydrogen sulfide (H2S) has a neuroprotective effect in neurodegenerative diseases. It is possible that this effect is supported by brain-derived neurotrophic factor (BDNF). Our aim is to examine the effects of H2S on neural damage in Parkinson's disease (PD) and to reveal the role of the BDNF-TrkB pathway in its possible effect. PD model was created with 1-methyl-phenyl-1,2,3,6-tetrahydropyridine (MPTP). C57BL/6 breed male mice were randomly divided into six groups: control, K252a, MPTP, MPTP + K252a, MPTP + NaHS, and MPTP + NaHS + K252a. TrkB receptor antagonist K252a and sodium hydrosulfide (NaHS) as a H2S donor were administered intraperitoneally. An increase was observed in the motor behavior tests in MPTP group, but NaHS treatment shortened the time spent on the balance beam and pole tests. It was also noticed that the BDNF-pathway played a role in the shortening of this period. Mice that received NaHS were found to have less MPTP-induced cellular damage. A positive effect of BDNF was also detected in the protection of these neurons. BDNF levels in the SN were significantly increased in MPTP group, compared to control group. Tissue CBS levels decreased in the groups that received K252a, compared to MPTP group. The findings of the present study display that the BDNF-TrkB pathway partially plays a role in the protective effect of H2S in the experimental mouse model of PD. This effect is probably due to changes in intracellular signaling pathways, rather than TrkB receptor expression.&lt;/p&gt;</description>
  </descriptions>
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