1 Ocak 2023 Dergi makalesi Açık Erişim

Birben, Esra; Sahiner, Umit Murat; Kalayci, Can Omer

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        "affiliation": "Hacettepe Univ, Fac Sci, Dept Biol, Ankara, Turkiye", 
        "name": "Birben, Esra"
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      {
        "affiliation": "Hacettepe Univ, Fac Med, Dept Pediat, Ankara, Turkiye", 
        "name": "Sahiner, Umit Murat"
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      {
        "affiliation": "Hacettepe Univ, Fac Med, Dept Pediat, Ankara, Turkiye", 
        "name": "Kalayci, Can Omer"
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    "description": "<p>Background/aim: Advanced glycation end products receptor (RAGE) is a pattern recognition receptor which attracted attention in chronic airway diseases recently. This study aimed to determine the association of RAGE with asthma and the cellular responses resulting from RAGE signaling pathway activation.Materials and methods: Asthmatic (n = 362) and healthy (n = 134) children were genotyped by PCR-RFLP. Plasma sRAGE levels were determined by ELISA. Lung structural cells were stimulated with AGEs (advanced glycation end products) and control BSA. Expressions of cytokines and protein levels were determined by real-time PCR and ELISA.Results: Gly82Ser and -374 T/A polymorphisms in RAGE gene were associated with lower plasma sRAGE levels (p &lt; 0.001 and p &lt; 0.025, respectively). AGE stimulation increased the expression of RAGE (p = 0.002), ICAM-1 (p = 0.010) and VCAM-1 (p = 0.002) in endothelial cells; TIMP-1 (p = 0.003) and MCP-1 (p = 0.005) in fibroblasts. AGE stimulation increased protein levels of IL-6 (p &lt; 0.001) in endothelial cells; VEGF (p = 0.025) and IL-8 (p &lt; 0.001) in fibroblasts; IL-1b (p &lt; 0.001) and VEGF (p = 0.007) in epithelial cells.Conclusion: Activation of RAGE pathway may contribute to asthma pathogenesis by increasing the expression of several asthma -related genes. These findings suggest that suppression of RAGE signaling may be an alternative candidate for treating asthma.</p>", 
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      "issue": "1", 
      "pages": "12", 
      "title": "TURKISH JOURNAL OF MEDICAL SCIENCES", 
      "volume": "53"
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    "publication_date": "2023-01-01", 
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    "title": "Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma"
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