1 Ocak 2023 Dergi makalesi Açık Erişim

Parlatan, Ugur; Ozen, Mehmet Ozgun; Kecoglu, Ibrahim; Koyuncu, Batuhan; Torun, Hulya; Khalafkhany, Davod; Loc, Irem; Ogut, Mehmet Giray; Inci, Fatih; Akin, Demir; Solaroglu, Ihsan; Ozoren, Nesrin; Unlu, Mehmet Burcin; Demirci, Utkan

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
    <subfield code="o">oai:aperta.ulakbim.gov.tr:271136</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Exosomes, nano-sized extracellular vesicles (EVs) secreted from cells, carry various cargo molecules reflecting their cells of origin. As EV content, structure, and size are highly heterogeneous, their classification via cargo molecules by determining their origin is challenging. Here, a method is presented combining surface-enhanced Raman spectroscopy (SERS) with machine learning algorithms to employ the classification of EVs derived from five different cell lines to reveal their cellular origins. Using an artificial neural network algorithm, it is shown that the label-free Raman spectroscopy method's prediction ratio correlates with the ratio of HT-1080 exosomes in the mixture. This machine learning-assisted SERS method enables a new direction through label-free investigation of EV preparations by differentiating cancer cell-derived exosomes from those of healthy. This approach will potentially open up new avenues of research for early detection and monitoring of various diseases, including cancer.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Parlatan, Ugur</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:f26b56f661002ad777031276dd29ad9d</subfield>
    <subfield code="s">285</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/271136/files/bib-6e0cdebb-1b7c-45b9-adeb-ca227f306b1f.txt</subfield>
  </datafield>
  <controlfield tag="005">20240607162755.0</controlfield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2023-01-01</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1002/smll.202205519</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Label-Free Identification of Exosomes using Raman Spectroscopy and Machine Learning</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="v">19</subfield>
    <subfield code="p">SMALL</subfield>
    <subfield code="c">12</subfield>
    <subfield code="n">9</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ozen, Mehmet Ozgun</subfield>
    <subfield code="u">Stanford Sch Med, Canary Ctr, BioAcoust MEMS Med Lab BAMM, Dept Radiol,Stanford Canc Early Detect, Palo Alto, CA 94304 USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Kecoglu, Ibrahim</subfield>
    <subfield code="u">Bogazici Univ, Dept Phys, TR-34342 Istanbul, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Koyuncu, Batuhan</subfield>
    <subfield code="u">Bogazici Univ, Dept Comp Engn, TR-34342 Istanbul, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Torun, Hulya</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Khalafkhany, Davod</subfield>
    <subfield code="u">Bogazici Univ, Ctr Life Sci &amp; Technol, Dept Mol Biol &amp; Genet, Apoptosis &amp; Canc Immunol Lab AKiL, TR-34342 Istanbul, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Loc, Irem</subfield>
    <subfield code="u">Bogazici Univ, Dept Phys, TR-34342 Istanbul, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ogut, Mehmet Giray</subfield>
    <subfield code="u">Stanford Sch Med, Canary Ctr, BioAcoust MEMS Med Lab BAMM, Dept Radiol,Stanford Canc Early Detect, Palo Alto, CA 94304 USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Inci, Fatih</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Akin, Demir</subfield>
    <subfield code="u">Stanford Sch Med, Canary Ctr, BioAcoust MEMS Med Lab BAMM, Dept Radiol,Stanford Canc Early Detect, Palo Alto, CA 94304 USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Solaroglu, Ihsan</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ozoren, Nesrin</subfield>
    <subfield code="u">Bogazici Univ, Ctr Life Sci &amp; Technol, Dept Mol Biol &amp; Genet, Apoptosis &amp; Canc Immunol Lab AKiL, TR-34342 Istanbul, Turkiye</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Unlu, Mehmet Burcin</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Demirci, Utkan</subfield>
    <subfield code="u">Stanford Sch Med, Canary Ctr, BioAcoust MEMS Med Lab BAMM, Dept Radiol,Stanford Canc Early Detect, Palo Alto, CA 94304 USA</subfield>
  </datafield>
  <controlfield tag="001">271136</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
</record>