1 Ocak 2024 Dergi makalesi Açık Erişim

Karayildirim, Cinel Koksal; Okur, Neslihan Ustundag; Okur, Mehmet Evren; Caglar, Emre Sefik; Nalbantsoy, Ayse; Alsakini, Karar Ali Mohammed Hasan; Yavasoglu, Nefise Ulku Karabay

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/270708</identifier>
  <creators>
    <creator>
      <creatorName>Karayildirim, Cinel Koksal</creatorName>
      <givenName>Cinel Koksal</givenName>
      <familyName>Karayildirim</familyName>
      <affiliation>Ege Univ, Fac Sci, Dept Biol, TR-35100 Izmir, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Okur, Neslihan Ustundag</creatorName>
      <givenName>Neslihan Ustundag</givenName>
      <familyName>Okur</familyName>
      <affiliation>Univ Hlth Sci, Fac Pharm, Dept Pharmaceut Technol, Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Okur, Mehmet Evren</creatorName>
      <givenName>Mehmet Evren</givenName>
      <familyName>Okur</familyName>
      <affiliation>Univ Hlth Sci, Fac Pharm, Dept Pharmacol, Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Caglar, Emre Sefik</creatorName>
      <givenName>Emre Sefik</givenName>
      <familyName>Caglar</familyName>
      <affiliation>Univ Hlth Sci, Fac Pharm, Dept Pharmaceut Biotechnol, Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Nalbantsoy, Ayse</creatorName>
      <givenName>Ayse</givenName>
      <familyName>Nalbantsoy</familyName>
      <affiliation>Ege Univ, Fac Engn, Dept Bioengn, Izmir, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Alsakini, Karar Ali Mohammed Hasan</creatorName>
      <givenName>Karar Ali Mohammed Hasan</givenName>
      <familyName>Alsakini</familyName>
      <affiliation>Ege Univ, Fac Engn, Dept Bioengn, Izmir, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Yavasoglu, Nefise Ulku Karabay</creatorName>
      <givenName>Nefise Ulku Karabay</givenName>
      <familyName>Yavasoglu</familyName>
      <affiliation>Ege Univ, Fac Sci, Dept Biol, TR-35100 Izmir, Turkiye</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Preparation, Characterization, And Toxicity Evaluation Of Microemulsion Formulation Containing Prunetin For Potential Oral Applications</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2024</publicationYear>
  <dates>
    <date dateType="Issued">2024-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/270708</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1080/01480545.2023.2282373</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Phytochemicals as therapeutic alternatives can have a fundamental impact on the various stages of inflammation and its resolution. Prunetin is a naturally occurring isoflavone and has been claimed to have numerous therapeutic potentials. The objective of this study is preparation, characterization, and toxicity evaluation of microemulsion formulation containing prunetin (PMF) for potential oral applications. With this research, it was targeted to emphasize the way of improving the therapeutic efficacy of natural biomolecules with a nontoxic and effective formulation. In the study, the pseudo-ternary phase diagram was developed and PMF was characterized by conductivity, droplet size, viscosity and pH. Effects against to cytokines (IL-1 beta and IL-6) and TNF-alpha levels of the PMF were determined by ELISA technique. Genotoxicity and acute oral toxicity tests were carried out according to OECD guidelines. The results showed that PMF is a colloid system that reduced proinflammatory cytokine levels in LPS-induced macrophage cells compared to the control group. PMF demonstrated no mutagenic activity against TA98, TA100, TA1535, and TA1537 Salmonella strains. The in vivo oral acute toxicity test results indicated that PMF did not show mortality or significant side effects even at 2000 mg/kg bw. This study represents PMF showed a good safety profile in animal study. It is thought that this formulation may have anti-inflammatory potential with further in vivo testing.&lt;/p&gt;</description>
  </descriptions>
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