1 Ocak 2023 Dergi makalesi Açık Erişim

Roth, Lynn; Dogan, Soner; Tuna, Bilge Guvenc; Aranyi, Tamas; Benitez, Sonia; Borrell-Pages, Maria; Bozaykut, Perinur; De Meyer, Guido R. Y.; Duca, Laurent; Durmus, Nergiz; Fonseca, Diogo; Fraenkel, Emil; Gillery, Philippe; Giudici, Alessandro; Jaisson, Stephane; Johansson, Madeleine; Julve, Josep; Lucas-Herald, Angela K.; Martinet, Wim; Maurice, Pascal

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    "creators": [
      {
        "affiliation": "Univ Antwerp, Lab Physiopharmacol, Univ Pl 1, B-2610 Antwerp, Belgium", 
        "name": "Roth, Lynn"
      }, 
      {
        "affiliation": "Yeditepe Univ, Sch Med, Dept Med Biol, Istanbul, Turkiye", 
        "name": "Dogan, Soner"
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      {
        "affiliation": "Yeditepe Univ, Sch Med, Dept Biophys, Istanbul, Turkiye", 
        "name": "Tuna, Bilge Guvenc"
      }, 
      {
        "name": "Aranyi, Tamas"
      }, 
      {
        "name": "Benitez, Sonia"
      }, 
      {
        "name": "Borrell-Pages, Maria"
      }, 
      {
        "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Fac Engn & Nat Sci, Dept Mol Biol & Genet, Istanbul, Turkiye", 
        "name": "Bozaykut, Perinur"
      }, 
      {
        "affiliation": "Univ Antwerp, Lab Physiopharmacol, Univ Pl 1, B-2610 Antwerp, Belgium", 
        "name": "De Meyer, Guido R. Y."
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      {
        "affiliation": "Univ Reims Champagne Ardenne URCA, CNRS, UMR Matrice Extracellulaire & Dynam Cellulaire ME, Team Matrix Aging & Vasc Remodelling 2, Reims, France", 
        "name": "Duca, Laurent"
      }, 
      {
        "affiliation": "Dokuz Eylul Univ, Dept Pharmacol, Fac Med, Izmir, Turkiye", 
        "name": "Durmus, Nergiz"
      }, 
      {
        "name": "Fonseca, Diogo"
      }, 
      {
        "affiliation": "Pavol Jozef Safarik Univ Kosice, Univ Hosp, Dept Internal Med 1, Kosice, Slovakia", 
        "name": "Fraenkel, Emil"
      }, 
      {
        "name": "Gillery, Philippe"
      }, 
      {
        "name": "Giudici, Alessandro"
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      {
        "name": "Jaisson, Stephane"
      }, 
      {
        "affiliation": "Lund Univ, Dept Clin Sci, Malmo, Sweden", 
        "name": "Johansson, Madeleine"
      }, 
      {
        "name": "Julve, Josep"
      }, 
      {
        "affiliation": "Univ Glasgow, Dev Endocrinol Res Grp, Glasgow, Lanark, Scotland", 
        "name": "Lucas-Herald, Angela K."
      }, 
      {
        "affiliation": "Univ Antwerp, Lab Physiopharmacol, Univ Pl 1, B-2610 Antwerp, Belgium", 
        "name": "Martinet, Wim"
      }, 
      {
        "affiliation": "Univ Reims Champagne Ardenne URCA, CNRS, UMR Matrice Extracellulaire & Dynam Cellulaire ME, Team Matrix Aging & Vasc Remodelling 2, Reims, France", 
        "name": "Maurice, Pascal"
      }
    ], 
    "description": "<p>Vascular ageing, characterized by structural and functional changes in blood vessels of which arterial stiffness and endothelial dysfunction are key components, is associated with increased risk of cardiovascular and other age-related diseases. As the global population continues to age, understanding the underlying mechanisms and developing effective therapeutic interventions to mitigate vascular ageing becomes crucial for improving cardiovascular health outcomes. Therefore, this review provides an overview of the current knowledge on pharmacological modulation of vascular ageing, highlighting key strategies and promising therapeutic targets. Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. Pharmacological and dietary interventions targeting these pathways have shown potential in ameliorating age-related vascular changes. Nevertheless, the development and application of drugs targeting vascular ageing is complicated by various inherent challenges and limitations, such as certain preclinical methodological considerations, interactions with exercise training and sex/gender-related differences, which should be taken into account. Overall, pharmacological modulation of endothelial dysfunction and arterial stiffness as hallmarks of vascular ageing, holds great promise for improving cardiovascular health in the ageing population. Nonetheless, further research is needed to fully elucidate the underlying mechanisms and optimize the efficacy and safety of these interventions for clinical translation.</p>", 
    "doi": "10.1016/j.arr.2023.102122", 
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    "journal": {
      "pages": "23", 
      "title": "AGEING RESEARCH REVIEWS", 
      "volume": "92"
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    "license": {
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    "publication_date": "2023-01-01", 
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    "title": "Pharmacological modulation of vascular ageing: A review from VascAgeNet"
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