1 Ocak 2023 Dergi makalesi Açık Erişim

Saylam, Merve; Kose, Fadime Aydin; Pabuccuoglu, Aysun; Celepci, Duygu Barut; Aygun, Muhittin; Pabuccuoglu, Varol

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/269902</identifier>
  <creators>
    <creator>
      <creatorName>Saylam, Merve</creatorName>
      <givenName>Merve</givenName>
      <familyName>Saylam</familyName>
      <affiliation>Izmir Katip Celebi Univ, Fac Pharm, Dept Pharmaceut Chem, Izmir, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Kose, Fadime Aydin</creatorName>
      <givenName>Fadime Aydin</givenName>
      <familyName>Kose</familyName>
      <affiliation>Izmir Katip Celebi Univ, Fac Pharm, Dept Biochem, Izmir, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Pabuccuoglu, Aysun</creatorName>
      <givenName>Aysun</givenName>
      <familyName>Pabuccuoglu</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Biochem, Izmir, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Celepci, Duygu Barut</creatorName>
      <givenName>Duygu Barut</givenName>
      <familyName>Celepci</familyName>
      <affiliation>Dokuz Eylul Univ, Fac Sci, Dept Phys, Izmir, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Aygun, Muhittin</creatorName>
      <givenName>Muhittin</givenName>
      <familyName>Aygun</familyName>
      <affiliation>Dokuz Eylul Univ, Fac Sci, Dept Phys, Izmir, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Pabuccuoglu, Varol</creatorName>
      <givenName>Varol</givenName>
      <familyName>Pabuccuoglu</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Chem, Izmir, Turkiye</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Design, Synthesis, And Biological Activity Studies On Benzimidazole Derivatives Targeting Myeloperoxidase</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2023</publicationYear>
  <dates>
    <date dateType="Issued">2023-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/269902</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ejmech.2022.115083</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Myeloperoxidase (MPO) plays a key role in human antimicrobial system by oxidizing vital molecules of mi-croorganisms in phagolysosomes through produced hypochlorous acid (HOCl). However, MPO can be released outside the phagocyte and produces reactive intermediates leading to tissue damage. MPO, as a local mediator of tissue damage, has been associated with inflammatory diseases such as renal injury, multiple sclerosis, cardio-vascular and neurodegenerative diseases. Therefore, the enzyme currently draws attention as a potential ther-apeutic target. In this study, isomeric 1,3-dihydro-2H-benzo[d]imidazole-2-thione derivatives having amide, hydrazide and hydroxamic acid groups either on nitrogen or on sulphur atom were designed and their inhibitory activity was determined on chlorination and peroxidation cycles of MPO. Among the compounds, 2-(2-thioxo-2,3-dihydro-1H-benzo[d]imidazole-1-yl)acetohydrazide (C19) was found as the most active inhibitor on both cycles.&lt;/p&gt;</description>
  </descriptions>
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