1 Ocak 2023 Dergi makalesi Açık Erişim

Cebi, Merve; Cakar, Arman; Erdogdu, Eren; Durmus-Tekce, Hacer; Yegen, Gulcin; Ozkan, Berker; Parman, Yesim; Saruhan-Direskeneli, Guher

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/269890</identifier>
  <creators>
    <creator>
      <creatorName>Cebi, Merve</creatorName>
      <givenName>Merve</givenName>
      <familyName>Cebi</familyName>
    </creator>
    <creator>
      <creatorName>Cakar, Arman</creatorName>
      <givenName>Arman</givenName>
      <familyName>Cakar</familyName>
      <affiliation>Istanbul Univ, Istanbul Med Fac, Dept Neurol, TR-34093 Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Erdogdu, Eren</creatorName>
      <givenName>Eren</givenName>
      <familyName>Erdogdu</familyName>
      <affiliation>Istanbul Univ, Istanbul Med Fac, Dept Thorac Surg, TR-34093 Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Durmus-Tekce, Hacer</creatorName>
      <givenName>Hacer</givenName>
      <familyName>Durmus-Tekce</familyName>
      <affiliation>Istanbul Univ, Istanbul Med Fac, Dept Neurol, TR-34093 Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Yegen, Gulcin</creatorName>
      <givenName>Gulcin</givenName>
      <familyName>Yegen</familyName>
      <affiliation>Istanbul Univ, Istanbul Med Fac, Dept Pathol, TR-34093 Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Ozkan, Berker</creatorName>
      <givenName>Berker</givenName>
      <familyName>Ozkan</familyName>
      <affiliation>Istanbul Univ, Istanbul Med Fac, Dept Thorac Surg, TR-34093 Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Parman, Yesim</creatorName>
      <givenName>Yesim</givenName>
      <familyName>Parman</familyName>
      <affiliation>Istanbul Univ, Istanbul Med Fac, Dept Neurol, TR-34093 Istanbul, Turkiye</affiliation>
    </creator>
    <creator>
      <creatorName>Saruhan-Direskeneli, Guher</creatorName>
      <givenName>Guher</givenName>
      <familyName>Saruhan-Direskeneli</familyName>
      <affiliation>Istanbul Univ, Istanbul Med Fac, Dept Physiol, TR-34093 Istanbul, Turkiye</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Thymoma Patients With Or Without Myasthenia Gravis Have Increased Th17 Cells, Il-17 Production And Icos Expression</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2023</publicationYear>
  <dates>
    <date dateType="Issued">2023-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/269890</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.jneuroim.2023.578129</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Thymoma associated myasthenia gravis (TAMG) is a small disease subgroup with autoantibodies against the acetylcholine receptor. The aim of this study was to assess the role of T helper (Th) cells in TAMG compared to thymoma patients without MG (TOMA) and healthy controls (HC). Peripheral blood cells were used for intracellular cytokine measurements and phenotyping of CD4+ Th cells. IL-21 and IL-4 productions and peripheral Th cells were higher in TAMG compared to TOMA patients and HC. Increases of ICOS and Th17 population were detected both in TAMG and TOMA groups. Higher IL-10 and Th1 population have been observed related to thymectomy. ICOS expression and Th17 induced by thymoma may contribute to the development of TAMG.&lt;/p&gt;</description>
  </descriptions>
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