Dergi makalesi Açık Erişim
Erdem, Serife; Haskologlu, Sule; Haliloglu, Yesim; Celikzencir, Huriye; Arik, Elif; Keskin, Ozlem; Eltan, Sevgi Bilgic; Yucel, Esra; Canatan, Halit; Avcilar, Huseyin; Yilmaz, Ebru; Ozcan, Alper; Unal, Ekrem; Karakukcu, Musa; Celiksoy, Mehmet Halil; Kilic, Sara Sebnem; Demir, Ayca; Genel, Ferah; Gulez, Nesrin; Koker, Mustafa Yavuz
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Alper</subfield> <subfield code="u">Erciyes Univ, Dept Pediat Hematol & Oncol, Sch Med, Kayseri, Turkiye</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Unal, Ekrem</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Karakukcu, Musa</subfield> <subfield code="u">Erciyes Univ, Dept Pediat Hematol & Oncol, Sch Med, Kayseri, Turkiye</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Celiksoy, Mehmet Halil</subfield> <subfield code="u">Univ Hlth Sci, Istanbul Basaksehir Cam & Sakura City Hosp, Pediat Allergy & Immunol Clin, Istanbul, Turkiye</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Kilic, Sara Sebnem</subfield> <subfield code="u">Bursa Uludag Univ, Sch Med, Dept Pediat Immunol & Rheumatol, Bursa, Turkiye</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Demir, Ayca</subfield> </datafield> <datafield tag="700" ind1=" " 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<subfield code="a">10.1016/j.clim.2023.109691</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Defective Treg generation and increased type 3 immune response in leukocyte adhesion deficiency 1</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Erdem, Serife</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:aperta.ulakbim.gov.tr:268622</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2023-01-01</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="u">https://aperta.ulakbim.gov.trrecord/268622/files/bib-461fd0ac-8e72-4f91-bf4e-6c87ab15c108.txt</subfield> <subfield 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The percentage of peripheral blood Treg cells, in vitro-generated induced Tregs differentiated from naive CD4+ T cells were decreased despite the elevated absolute counts of CD4+ cells in LAD-1 patients. Serum IL-23 levels were elevated in LAD-1 patients. Post-curdlan stimulation, LAD-1 patient-derived PBMCs produced more IL-17A. Additionally, the percentages of CD18-deficient Th17 cells expanded from total or naive CD4+ T cells were higher. The blood ILC3 subset was significantly elevated in LAD-1. Finally, LAD-1 PBMCs showed defects in trans-well migration and proliferation and were more resistant to apoptosis. Defects in de novo generation of Tregs from CD18-deficient naive T cells and elevated Th17s, and ILC3s in LAD1 patients' peripheral blood suggest a type 3-skewed immunity and may contribute to LAD-1-associated autoimmune symptoms.</p></subfield> </datafield> </record>
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