1 Ocak 2023 Dergi makalesi Açık Erişim

Delik, Eda; Eroglu, Berfin; colak, Cigdem Yilmaz; Ozcelik, Aysun Turkanoglu; Ozturk, Burcu Emine Tefon

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{
  "@context": "https://schema.org/", 
  "@id": 265604, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Akdeniz Univ, Fac Sci, Biol Dept, TR-07058 Antalya, Turkiye", 
      "name": "Delik, Eda"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Akdeniz Univ, Fac Sci, Biol Dept, TR-07058 Antalya, Turkiye", 
      "name": "Eroglu, Berfin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "TUBITAK, Genet Engn & Biotechnol Inst, TR-41470 Kocaeli, Turkiye", 
      "name": "colak, Cigdem Yilmaz"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Akdeniz Univ, Fac Agr, Agr Biotechnol Dept, TR-07058 Antalya, Turkiye", 
      "name": "Ozcelik, Aysun Turkanoglu"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Akdeniz Univ, Fac Sci, Biol Dept, TR-07058 Antalya, Turkiye", 
      "name": "Ozturk, Burcu Emine Tefon"
    }
  ], 
  "datePublished": "2023-01-01", 
  "description": "<p>Bordetella pertussis is the primary agent of the acute respiratory disease pertussis. It has been reported that the disease has recently become more common, especially in adults and adolescents, and adaptation of the pathogen is thought to have an important influence on the recurrence of the disease. This study aims to determine the effect of erythromycin, azithromycin, and trimethoprim-sulfamethoxazole used in the treatment of pertussis on the virulence gene expressions (prn, ptxS1, fhaB), biofilm-forming and growth of B. pertussis. In this study, the minimum inhibitory concentration (MIC) values of azithromycin and erythromycin in B. pertussis local strain Saadet were determined to be 0.09 mg/mL and 0.3 mg/mL, respectively. However, the Tohama-I and Saadet strains were resistant to trimethoprim-sulfamethoxazole (MIC&gt;32 mg/mL). The biofilm-forming of the Saadet strain decreased with the in-crease in antibiotic doses. It was observed that 1/32MIC erythromycin and 1/32MIC azithromycin upregulated the expression of fhaB in Tohama-I, whereas the expression of ptxS1 and prn significantly decreased in sub-MICs of erythromycin. In the Saadet strain, only ptxS1 was highly expressed at 1/16MIC azithromycin and erythromycin (p &gt; 0.05). This is the first study to investigate the effect of sub-MIC antibiotics on the expression of virulence genes and biofilm-forming of B. pertussis.&amp; COPY; 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.</p>", 
  "headline": "Alterations of growth, biofilm-forming, and gene expression of<i> Bordetella</i><i> pertussis</i> by antibiotics at sub-minimum inhibitory concentrations", 
  "identifier": 265604, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Alterations of growth, biofilm-forming, and gene expression of<i> Bordetella</i><i> pertussis</i> by antibiotics at sub-minimum inhibitory concentrations", 
  "url": "https://aperta.ulakbim.gov.tr/record/265604"
}