Dergi makalesi Açık Erişim
Yakici, Nalan; Kreins, Alexandra Y.; Catak, Mehmet Cihangir; Babayeva, Royala; Erman, Baran; Kenney, Heather; Gungor, Hatice Eke; Cea, Pablo A.; Kawai, Tomoki; Bosticardo, Marita; Delmonte, Ottavia Maria; Adams, Stuart; Fan, Yu-Tong; Pala, Francesca; Turkyilmaz, Ayberk; Howley, Evey; Worth, Austen; Kot, Hakan; Sefer, Asena Pinar; Kara, Altan
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We described six new patients who demonstrated variable clinical penetrance. Reduced transcriptional activity of pathogenic variants confirmed partial or complete PAX1 deficiency. Thymic aplasia and hypoplasia were associated with impaired T cell immunity. Corrective treatment was required in 4/6 patients. Hematopoietic stem cell transplantation resulted in poor immune reconstitution with absent naive T cells, contrasting with the superior recovery of T cell immunity after thymus transplantation. Normal ex vivo differentiation of PAX1-deficient CD34+ cells into mature T cells demonstrated the absence of a hematopoietic cell-intrinsic defect. New overlapping features with DiGeorge syndrome included primary hypoparathyroidism (n = 5) and congenital heart defects (n = 2), in line with PAX1 expression during early embryogenesis. Our results highlight new features of PAX1 deficiency, which are relevant to improving early diagnosis and identifying patients requiring corrective treatment.</p>", "doi": "10.1016/j.clim.2023.109757", "has_grant": false, "journal": { "pages": "14", "title": "CLINICAL IMMUNOLOGY", "volume": "255" }, "license": { "id": "cc-by" }, "publication_date": "2023-01-01", "relations": { "version": [ { "count": 1, "index": 0, "is_last": true, "last_child": { "pid_type": "recid", "pid_value": "265012" }, "parent": { "pid_type": "recid", "pid_value": "265011" } } ] }, "resource_type": { "subtype": "article", "title": "Dergi makalesi", "type": "publication" }, "science_branches": [ "Di\u011fer" ], "title": "Expanding the clinical and immunological phenotypes of PAX1-deficient SCID and CID patients" }, "owners": [ 1 ], "revision": 1, "stats": { "downloads": 0.0, "unique_downloads": 0.0, "unique_views": 1.0, "version_downloads": 0.0, "version_unique_downloads": 0.0, "version_unique_views": 1.0, "version_views": 1.0, "version_volume": 0.0, "views": 1.0, "volume": 0.0 }, "updated": "2024-06-07T11:18:02.011503+00:00" }
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