1 Ocak 2023 Dergi makalesi Açık Erişim

Bulut, Aliye; Temur, Betul Z.; Kirimli, Ceyhun E.; Gok, Ozgul; Balcioglu, Bertan K.; Ozturk, Hasan U.; Uyar, Neval Y.; Kanlidere, Zeynep; Kocagoz, Tanil; Can, Ozge

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{
  "@context": "https://schema.org/", 
  "@id": 264998, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bogazici Univ, Inst Biomed Engn, Dept Biomed Engn, TR-34684 Istanbul, Turkiye", 
      "name": "Bulut, Aliye"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Inst Hlth Sci, Dept Med Biotechnol, TR-34752 Istanbul, Turkiye", 
      "name": "Temur, Betul Z."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34752 Istanbul, Turkiye", 
      "name": "Kirimli, Ceyhun E."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34752 Istanbul, Turkiye", 
      "name": "Gok, Ozgul"
    }, 
    {
      "@type": "Person", 
      "affiliation": "TUBITAK, Genet Engn & Biotechnol Inst, Marmara Res Ctr, TR-41470 Kocaeli, Turkiye", 
      "name": "Balcioglu, Bertan K."
    }, 
    {
      "@type": "Person", 
      "affiliation": "TUBITAK, Genet Engn & Biotechnol Inst, Marmara Res Ctr, TR-41470 Kocaeli, Turkiye", 
      "name": "Ozturk, Hasan U."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Labmed Clin Labs, TR-34752 Istanbul, Turkiye", 
      "name": "Uyar, Neval Y."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Fac Pharm, Dept Basic Pharmaceut Sci, TR-34752 Istanbul, Turkiye", 
      "name": "Kanlidere, Zeynep"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Sch Med, Dept Med Microbiol, TR-34752 Istanbul, Turkiye", 
      "name": "Kocagoz, Tanil"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Acibadem Mehmet Ali Aydinlar Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34752 Istanbul, Turkiye", 
      "name": "Can, Ozge"
    }
  ], 
  "datePublished": "2023-01-01", 
  "description": "<p>The need for rapidly developed diagnostic tests has gained significant attention after the recent pandemic. Production of neutralizing antibodies for vaccine development or antibodies to be used in diagnostic tests usually require the usage of recombinant proteins representing the infectious agent. However, peptides that can mimic these recombinant proteins may be rapidly utilized, especially in emergencies such as the recent outbreak. Here, we report two peptides that mimic the receptor binding domain of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and investigate their binding behavior against the corresponding human immunoglobulin G and immunoglobulin M (IgG and IgM) antibodies in a clinical sample using a quartz crystal microbalance (QCM) sensor. These peptides were immobilized on a QCM sensor surface, and their binding behavior was studied against a clinical serum sample that was previously determined to be IgG and IgM-positive. It was determined that designed peptides bind to SARS-CoV-2 antibodies in a clinical sample. These peptides might be useful for the detection of SARS-CoV-2 antibodies using different methods such as enzyme-linked immunosorbent assay (ELISA) or lateral flow assays. A similar platform might prove to be useful for the detection and development of antibodies in other infections.</p>", 
  "headline": "A Novel Peptide-Based Detection of SARS-CoV-2 Antibodies", 
  "identifier": 264998, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "A Novel Peptide-Based Detection of SARS-CoV-2 Antibodies", 
  "url": "https://aperta.ulakbim.gov.tr/record/264998"
}