6 Mart 2024 Kitap bölümü Açık Erişim

Yücel, Levent; Yılmaz, Yavuz Fuat

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    "description": "<p>Ba\u015f boyun skuam\u00f6z h\u00fccreli kanserleri (BBSHK), d\u00fcnya \u00e7ap\u0131nda t\u00fcm kanserlerin en s\u0131k g\u00f6r\u00fc- len yedinci grubudur ve larenks kanseri \u00fcst aerodigestif trakt\u0131n ikinci en s\u0131k g\u00f6r\u00fclen malignitesidir. \u00d6zellikle skuam\u00f6z h\u00fccreli kanserleri ile ili\u015fkili karsinogenez geli\u015fiminde \u00f6nemli bir rol oynad\u0131\u011f\u0131 g\u00f6s- terilen bir\u00e7ok risk fakt\u00f6r\u00fc bulunmaktad\u0131r. Larenks kanser etiyolojisinde baz\u0131 ajanlar ile kesin neden- sonu\u00e7 ili\u015fkisi g\u00f6sterirken, baz\u0131lar\u0131n\u0131n ise ara\u015ft\u0131rmas\u0131 devam etmekte ya da hipotez olarak kalm\u0131\u015ft\u0131r. BBSHK \u00e7ok a\u015famal\u0131 karsinojenezin molek\u00fcler ilerleme modeli s\u00f6z konusudur. Bu model sigara, alkol ya da di\u011fer risk fakt\u00f6rlerine maruziyet etkisiyle normal mukozadan invaziv skuam\u00f6z h\u00fccreli kansere d\u00f6n\u00fc\u015f\u00fcm basamaklar\u0131n\u0131 i\u00e7ermekte, \u00e7e\u015fitli gen mutasyonlar\u0131na neden olmakta ve asl\u0131nda karsinogene- zin de temel basamaklar\u0131n\u0131 olu\u015fturmaktad\u0131r. Larenks kanserlerinin prognozu multifakt\u00f6ryeldir ve genel olarak hasta ba\u011fl\u0131 (ya\u015f, cinsiyet, beslenme durumu, fiziksel ve psikolojik performans durumu, e\u015flik eden hastal\u0131klar ve imm\u00fcnolojik etki), t\u00fcm\u00f6re ba\u011fl\u0131 (lokalizasyonu, TNM evresi, diferansiyasyonu ve senkron veya metakron ikincil bir primer kanserin varl\u0131\u011f\u0131) ve tedaviye ba\u011fl\u0131 (kemoradyoterapi, rad- yoterapi, cerrahi veya kombinasyonlar\u0131) fakt\u00f6rler olarak s\u0131n\u0131fland\u0131rabilir. Bu b\u00f6l\u00fcmde g\u00fcncel literat\u00fcr baz al\u0131narak larenks kanserlerinde etiyoloji, patogenez ve prognostik fakt\u00f6rler \u00f6zetlenmi\u015ftir.</p>", 
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