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Arslan, Serdal; Bakir, Mehmet; Bayyurt, Burcu; Aydemir, Eylem, I; Kinaci, Kenan; Engin, Aynur
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd"> <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/261947</identifier> <creators> <creator> <creatorName>Arslan, Serdal</creatorName> <givenName>Serdal</givenName> <familyName>Arslan</familyName> <affiliation>Mersin Univ, Fac Med, Dept Med Biol, TR-33343 Mersin, Turkey</affiliation> </creator> <creator> <creatorName>Bakir, Mehmet</creatorName> <givenName>Mehmet</givenName> <familyName>Bakir</familyName> <affiliation>Sivas Cumhuriyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey</affiliation> </creator> <creator> <creatorName>Bayyurt, Burcu</creatorName> <givenName>Burcu</givenName> <familyName>Bayyurt</familyName> <affiliation>Sivas Cumhuriyet Univ, Fac Med, Dept Med Biol, Sivas, Turkey</affiliation> </creator> <creator> <creatorName>Aydemir, Eylem, I</creatorName> <affiliation>Sivas Cumhuriyet Univ, Fac Sci, Dept Stat, Sivas, Turkey</affiliation> </creator> <creator> <creatorName>Kinaci, Kenan</creatorName> <givenName>Kenan</givenName> <familyName>Kinaci</familyName> <affiliation>SEM Labs, Istanbul, Turkey</affiliation> </creator> <creator> <creatorName>Engin, Aynur</creatorName> <givenName>Aynur</givenName> <familyName>Engin</familyName> <affiliation>Sivas Cumhuriyet Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey</affiliation> </creator> </creators> <titles> <title>Long Noncoding Rna Expression Analysis In Crimean Congo Hemorrhagic Fever Patients</title> </titles> <publisher>Aperta</publisher> <publicationYear>2022</publicationYear> <dates> <date dateType="Issued">2022-01-01</date> </dates> <resourceType resourceTypeGeneral="Text">Journal article</resourceType> <alternateIdentifiers> <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/261947</alternateIdentifier> </alternateIdentifiers> <relatedIdentifiers> <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/jmv.27721</relatedIdentifier> </relatedIdentifiers> <rightsList> <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights> <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights> </rightsList> <descriptions> <description descriptionType="Abstract">Crimean Congo hemorrhagic fever (CCHF) is an acute viral infection that can cause death. The detection of host transcriptome is important for understanding differences in the pathogenesis of the disease. Long noncoding RNAs (lncRNAs) regulate gene expression in different biological processes. They have also emerged as key molecules for therapeutic targets. We investigated the lncRNA gene expression profiles by utilizing the microarray for the first time in CCHF. LncRNAs were determined by the comparisons between case-control, fatal case-control, and fatal case-nonfatal cases. Quantitative polymerase chain reaction was applied to validate the microarray results of some lncRNAs. In our study, 39 lncRNAs (5 downregulated and 34 upregulated) were found to be significantly regulated in the cases when compared to the controls (p &lt; 0.05; FC &gt;= 2). One hundred ten lncRNAs exhibited a statistically significant difference between fatal cases and controls. FER1L4, ECRP, and LOC100133669 are important lncRNAs in both case and fatal case groups compared with controls. These lncRNAs may be considered important therapeutic targets for the CCHF in further studies.</description> </descriptions> </resource>
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