1 Ocak 2022 Dergi makalesi Açık Erişim

Ozkan, Asuman Deveci; Eskiler, Gamze Guney; Sarihan, Mehmet; Kazan, Nur; Aksoy, Ozlem; Yuksel, Burcu; Betts, Zeynep

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Eskiler, Gamze Guney</subfield>
    <subfield code="u">Sakarya Univ, Fac Med, Dept Med Biol, Sakarya, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Sarihan, Mehmet</subfield>
    <subfield code="u">Kocaeli Univ, Fac Med, Dept Med Biol, Kocaeli, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Kazan, Nur</subfield>
    <subfield code="u">Sakarya Univ, Inst Hlth Sci, Dept Med Biol, Sakarya, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Aksoy, Ozlem</subfield>
    <subfield code="u">Kocaeli Univ, Fac Sci &amp; Art, Dept Biol, Kocaeli, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Yuksel, Burcu</subfield>
    <subfield code="u">Kocaeli Univ, Kocaeli Vocat Sch Hlth Serv, Dept Med Serv &amp; Tech, Kocaeli, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Betts, Zeynep</subfield>
    <subfield code="u">Kocaeli Univ, Fac Sci &amp; Art, Dept Biol, Kocaeli, Turkey</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS</subfield>
    <subfield code="v">28</subfield>
    <subfield code="n">4</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1007/s10989-022-10428-8</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Anticancer Properties of Eisenia Foetida Proteins in Prostate Cancer Cells In Vitro</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Ozkan, Asuman Deveci</subfield>
    <subfield code="u">Sakarya Univ, Fac Med, Dept Med Biol, Sakarya, Turkey</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:aperta.ulakbim.gov.tr:261015</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2022-01-01</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/261015/files/bib-971ae7ae-6ded-48ae-89df-b337a7151f61.txt</subfield>
    <subfield code="z">md5:9ef93b42db524fc948256cbe259d6697</subfield>
    <subfield code="s">241</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <controlfield tag="005">20230729141056.0</controlfield>
  <controlfield tag="001">261015</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">Earthworms are tube-shaped, segmental worms and have a double transport system consisting of earthworm coelomic fluid (ECF) moving within the fluid-filled colon. As one of the naturally available extracts (NAEs), ECF exerts different biological functions, such as inhibiting the proliferation of cancer cells. Pharmacokinetic limitations in prostate cancer (PCa) treatment and undesirable side effects of chemotherapeutic drugs necessitate the discovery of new anticancer agents. Recent studies have focused on the antitumor activity of different regions of earthworms as a new potential anticancer agent. However, there are limited findings on the potential effects of ECF on PCa cells in vitro. Therefore, we aimed to evaluate the potential anticancer effects of ECF (obtained from Eisenia foetida) on two different types of PCa cells. In this study, the protein content of ECF, the most effective dose and incubation time and potentially genotoxic and apoptotic effects were determined in PC-3 and LNCaP cells for the first time. Bax and Bcl-2 gene and protein expression levels were determined by real-time polymerase chain reaction (RT-PCR) and western blotting, respectively. ECF increased apoptotic cell death; however, it did not have a significant genotoxic effect on PCa cells. The apoptotic effect of ECF in PCa cells varies according to the AR status and is more effective in AR-insensitive cells (PC-3). Therefore, our results will specifically support the pharmacological development of ECF as a potential anticancer molecule in the treatment of PCa in the future.</subfield>
  </datafield>
</record>