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Preparation of collagen modified photopolymers: a new type of biodegradable gel for cell growth

Bayramoglu, Guelay; Kayaman-Apohan, Nilhan; Akcakaya, Handan; Kahraman, Memet Vezir; Kuruca, Serap Erdem; Gungor, Atilla


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/25891</identifier>
  <creators>
    <creator>
      <creatorName>Bayramoglu, Guelay</creatorName>
      <givenName>Guelay</givenName>
      <familyName>Bayramoglu</familyName>
    </creator>
    <creator>
      <creatorName>Kayaman-Apohan, Nilhan</creatorName>
      <givenName>Nilhan</givenName>
      <familyName>Kayaman-Apohan</familyName>
      <affiliation>Marmara Univ, Dept Chem, TR-34722 Goztepe, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akcakaya, Handan</creatorName>
      <givenName>Handan</givenName>
      <familyName>Akcakaya</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, TR-34390 Capa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kahraman, Memet Vezir</creatorName>
      <givenName>Memet Vezir</givenName>
      <familyName>Kahraman</familyName>
      <affiliation>Marmara Univ, Dept Chem, TR-34722 Goztepe, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kuruca, Serap Erdem</creatorName>
      <givenName>Serap Erdem</givenName>
      <familyName>Kuruca</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, TR-34390 Capa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gungor, Atilla</creatorName>
      <givenName>Atilla</givenName>
      <familyName>Gungor</familyName>
      <affiliation>Marmara Univ, Dept Chem, TR-34722 Goztepe, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Preparation Of Collagen Modified Photopolymers: A New Type Of Biodegradable Gel For Cell Growth</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2010</publicationYear>
  <dates>
    <date dateType="Issued">2010-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/25891</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s10856-009-3929-4</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In this study a new branched methacrylated poly(propylene glycol-co-lactic acid) (PPG-PLA-IEM) and methacrylated cellulose acetate butyrate resin (CAB-IEM) were synthesized. Hydrogels with various amounts of PPG-PLA-IEM and CAB-IEM (25, 50 and 75 wt% IEM modified) were prepared by photopolymerization. Collagen tethered PEG-monoacrylate (PEGMA-collagen) was prepared and introduced as a bioactive moiety to modify the hydrogel in order to enhance cell affinity. In vitro attachment and growth of 3T3 mouse fibroblasts and human umbilical vein endothelial cells (HUVEC) on the hydrogels with and without collagen were also investigated. It was observed that, the collagen improves the cell adhesion onto the hydrogel surface. With the increasing amount of collagen, cell viability increased by 28% for ECV304 (P &amp;lt; 0.05) and 30% for 3T3 (P &amp;lt; 0.05).</description>
  </descriptions>
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