1 Ocak 2023 Dergi makalesi Açık Erişim

Yilmaz, Mahmut Muhsin; Akdere, Ozge Ekin; Gumusderelioglu, Menemse; Bayrak, Gokce Kaynak; Koc, Sena; Erdem, Aysen; Tuncer, Meltem; Atalay, Ozbeyen; Kaplanoglu, Gulnur Take; Dizakar, Saadet Ozen Akarca; Calis, Mert

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  "@context": "https://schema.org/", 
  "@id": 258261, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Plast Reconstruct & Aesthet Surg, Fac Med, TR-06100 Ankara, Turkey", 
      "name": "Yilmaz, Mahmut Muhsin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Bioengn Dept, Ankara, Turkey", 
      "name": "Akdere, Ozge Ekin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Bioengn & Chem Engn Dept, Ankara, Turkey", 
      "name": "Gumusderelioglu, Menemse"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Izmir Bakircay Univ, Biomed Engn Dept, Izmir, Turkey", 
      "name": "Bayrak, Gokce Kaynak"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Chem Engn Dept, Ankara, Turkey", 
      "name": "Koc, Sena"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Physiol, Ankara, Turkey", 
      "name": "Erdem, Aysen"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Physiol, Ankara, Turkey", 
      "name": "Tuncer, Meltem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Physiol, Ankara, Turkey", 
      "name": "Atalay, Ozbeyen"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Dept Histol & Embryol, Ankara, Turkey", 
      "name": "Kaplanoglu, Gulnur Take"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Gazi Univ, Dept Histol & Embryol, Ankara, Turkey", 
      "name": "Dizakar, Saadet Ozen Akarca"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Plast Reconstruct & Aesthet Surg, Fac Med, TR-06100 Ankara, Turkey", 
      "name": "Calis, Mert"
    }
  ], 
  "datePublished": "2023-01-01", 
  "description": "In this study, a biological conduit, consisting of an adipocyte-derived mesenchymal stem cell (AdMSCs) sheet and amniotic membrane (AM), was designed for the reconstruction of peripheral nerve defects. To evaluate the effect of the produced conduit on neural regeneration, a 10-mm sciatic nerve defect was created in rats, and experiments were carried out on six groups, i.e., sham control group (SC), negative control group (NC), nerve autograft group (NG), the biological conduit (AdMSCs + AM) group, the commercial PGA tube conduit (PGA) group, and the conduit only consisting of AM (AM) group. The effects of different nerve repair methods on the peripheral nerve and gastrocnemius muscle were evaluated by functional, histological, and immunohistochemical tests. When the number of myelinated axons was compared between the groups of AdMSCs + AM and PGA, it was higher in the AdMSCs + AM group (p < 0.05). The percentage of gastrocnemius collagen bundle area of AdMSCs + AM group was found to be statistically lower than the PGA group (p < 0.05). The muscle fiber diameter of AdMSCs + AM group was lower than that of the NG group, but significantly higher than that of the PGA group and the AM group (p < 0.001). Muscle weight index was significantly higher in the AdMSCs + AM group compared to the PGA group (p < 0.05). It was observed that nerve regeneration was faster in the AdMSCs + AM group, and there was an earlier improvement in pin-prick score and sciatic functional index compared to the PGA group and the AM group. In conclusion, the biological conduit prepared from the AdMSCs sheet and AM is regarded as a new biological conduit that can be used as an alternative treatment method to nerve autograft in clinical applications.", 
  "headline": "Biological nerve conduit model with de-epithelialized human amniotic membrane and adipose-derived mesenchymal stem cell sheet for repair of peripheral nerve defects", 
  "identifier": 258261, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Biological nerve conduit model with de-epithelialized human amniotic membrane and adipose-derived mesenchymal stem cell sheet for repair of peripheral nerve defects", 
  "url": "https://aperta.ulakbim.gov.tr/record/258261"
}