1 Ocak 2022 Dergi makalesi Açık Erişim

Kalkanli Tas, Sevgi; Uzunoglu, Merve Saide; Uzunoglu, Aylin Seher; Kirkik, Duygu; Altunkanat, Derya; Kalkanli, Nevin

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{
  "DOI": "10.55730/1300-0152.2579", 
  "abstract": "Coronavirus disease 2019 (COVID-19) pandemic has been an important global interest that affected millions of people, and it requires a deep investigation of the disease immunology for developing further therapeutic applications. Adoptive T cell therapy promises to address T cell-dependent immune dysregulation in COVID-19 patients by the generation of specific T cell clones against virus-specific antigens. Additionally, targeting B cell-dependent protection through COVID-19 vaccines, which have been developed in the recent year, possessed sufficient prevention for spreading the virus, since the cases and deaths related to COVID-19 tend to decrease after the vaccination. However, adoptive cell therapies are now encouraging scientists to deal with pathological challenges like inadequate T cell-dependent immune response or lymphopenia, since they are the most frequent outcome of severe infection, especially in immunocompromized patients. In this review, the current knowledge of immunopathology of COVID-19 was aimed to be highlighted along with the T cell responses against SARS-CoV-2 to comprise a basis for therapeutics. Moreover, current therapeutics and treatment strategies for COVID-19 were discussed to evaluate possible agents. Furthermore, the use of adoptive T cell therapy representing an emerging therapeutic approach was purposed to be presented comprehensively against SARS-CoV-2 infection. Even though further studies are needed to fully understand T cell response against SARS-CoV-2 in order to develop therapies to provide long term and efficient protection, adoptive cell therapies now meet the demand for a large population of people who suffer immunocompromization, considering the previous usage of the technique for different infectious diseases.", 
  "author": [
    {
      "family": "Kalkanli Tas", 
      "given": " Sevgi"
    }, 
    {
      "family": "Uzunoglu", 
      "given": " Merve Saide"
    }, 
    {
      "family": "Uzunoglu", 
      "given": " Aylin Seher"
    }, 
    {
      "family": "Kirkik", 
      "given": " Duygu"
    }, 
    {
      "family": "Altunkanat", 
      "given": " Derya"
    }, 
    {
      "family": "Kalkanli", 
      "given": " Nevin"
    }
  ], 
  "container_title": "TURKISH JOURNAL OF BIOLOGY", 
  "id": "256005", 
  "issue": "2", 
  "issued": {
    "date-parts": [
      [
        2022, 
        1, 
        1
      ]
    ]
  }, 
  "page": "105-117", 
  "title": "Adoptive T-cell therapies to overcome T cell-dependent immune dysregulations in COVID-19", 
  "type": "article-journal", 
  "volume": "46"
}