1 Ocak 2022 Dergi makalesi Açık Erişim

Spellerberg, Rebekka; Benli-Hoppe, Teoman; Kitzberger, Carolin; Hageneier, Mara; Schwenk, Nathalie; Oeztuerk, Oezguer; Steiger, Katja; Multhoff, Gabriele; Eiber, Matthias; Schilling, Franz; Weber, Wolfgang A.; Kaelin, Roland E.; Glass, Rainer; Nelson, Peter J.; Wagner, Ernst; Spitzweg, Christine

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/255475</identifier>
  <creators>
    <creator>
      <creatorName>Spellerberg, Rebekka</creatorName>
      <givenName>Rebekka</givenName>
      <familyName>Spellerberg</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Dept Internal Med 4, LMU Univ Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Benli-Hoppe, Teoman</creatorName>
      <givenName>Teoman</givenName>
      <familyName>Benli-Hoppe</familyName>
    </creator>
    <creator>
      <creatorName>Kitzberger, Carolin</creatorName>
      <givenName>Carolin</givenName>
      <familyName>Kitzberger</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Dept Internal Med 4, LMU Univ Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Hageneier, Mara</creatorName>
      <givenName>Mara</givenName>
      <familyName>Hageneier</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Dept Internal Med 4, LMU Univ Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Schwenk, Nathalie</creatorName>
      <givenName>Nathalie</givenName>
      <familyName>Schwenk</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Dept Internal Med 4, LMU Univ Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Oeztuerk, Oezguer</creatorName>
      <givenName>Oezguer</givenName>
      <familyName>Oeztuerk</familyName>
    </creator>
    <creator>
      <creatorName>Steiger, Katja</creatorName>
      <givenName>Katja</givenName>
      <familyName>Steiger</familyName>
      <affiliation>Tech Univ Munich, Sch Med, Inst Pathol, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Multhoff, Gabriele</creatorName>
      <givenName>Gabriele</givenName>
      <familyName>Multhoff</familyName>
      <affiliation>Tech Univ Munich, Ctr Translat Canc Res, Sch Med, Radiat Immunooncol Grp,Klinikum Rechts Isar, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Eiber, Matthias</creatorName>
      <givenName>Matthias</givenName>
      <familyName>Eiber</familyName>
      <affiliation>Tech Univ Munich, Sch Med, Dept Nucl Med, Klinikum Rechts Isar, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Schilling, Franz</creatorName>
      <givenName>Franz</givenName>
      <familyName>Schilling</familyName>
      <affiliation>Tech Univ Munich, Sch Med, Dept Nucl Med, Klinikum Rechts Isar, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Weber, Wolfgang A.</creatorName>
      <givenName>Wolfgang A.</givenName>
      <familyName>Weber</familyName>
      <affiliation>Tech Univ Munich, Sch Med, Dept Nucl Med, Klinikum Rechts Isar, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Kaelin, Roland E.</creatorName>
      <givenName>Roland E.</givenName>
      <familyName>Kaelin</familyName>
    </creator>
    <creator>
      <creatorName>Glass, Rainer</creatorName>
      <givenName>Rainer</givenName>
      <familyName>Glass</familyName>
    </creator>
    <creator>
      <creatorName>Nelson, Peter J.</creatorName>
      <givenName>Peter J.</givenName>
      <familyName>Nelson</familyName>
      <affiliation>Ludwig Maximilians Univ Munchen, Dept Internal Med 4, LMU Univ Hosp, Munich, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Wagner, Ernst</creatorName>
      <givenName>Ernst</givenName>
      <familyName>Wagner</familyName>
    </creator>
    <creator>
      <creatorName>Spitzweg, Christine</creatorName>
      <givenName>Christine</givenName>
      <familyName>Spitzweg</familyName>
    </creator>
  </creators>
  <titles>
    <title>Dual Egfr- And Tfr-Targeted Gene Transfer For Sodium Iodide Symporter Gene Therapy Of Glioblastoma</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2022</publicationYear>
  <dates>
    <date dateType="Issued">2022-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/255475</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.omto.2022.10.013</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Sodium iodide symporter (NIS) gene transfer for active accumulation of iodide in tumor cells is a powerful theranostic strategy facilitating both diagnostic and therapeutic application of radioiodide. In glioblastoma (GBM), the blood-brain barrier (BBB) presents an additional delivery barrier for nucleic acid nanoparticles. In the present study, we designed dual-targeted NIS plasmid DNA complexes containing targeting ligands for the transferrin receptor (TfR) and the epidermal growth factor receptor (EGFR), thus providing the potential for active transport across the BBB followed by targeting of tumor cells. In vitro 125I transfection studies confirmed TfR- and EGFR-dependent transfection efficiency and NIS-specific iodide uptake of dual-targeted polyplexes. In vivo gene transfer in mice bearing orthotopic U87 GBM xenografts was assessed at 48 h after intravenous polyplex injection by positron emission tomography (PET) imaging using 18F-labeled tetrafluoroborate (TFB) as tracer. The tumoral 18F-TFB uptake of mice treated with dual-targeted polyplexes (0.56% +/- 0.08% ID/mL) was significantly higher compared with mice treated with EGFR-mono-targeted (0.33% +/- 0.03% ID/mL) or TfR-monotargeted (0.27% +/- 0.04% ID/mL) polyplexes. In therapy studies, application of 131I induced a superior therapeutic effect of the dual-targeted therapy, demonstrated by a significant delay in tumor growth and prolonged survival.</description>
  </descriptions>
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