1 Ocak 2010 Dergi makalesi Açık Erişim

Timurdogan, Erman; Ozber, Natali; Nargul, Sezin; Yavuz, Serhat; Kilic, M. Salih; Kavakli, I. Halil; Urey, Hakan; Alaca, B. Erdem

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/25545</identifier>
  <creators>
    <creator>
      <creatorName>Timurdogan, Erman</creatorName>
      <givenName>Erman</givenName>
      <familyName>Timurdogan</familyName>
      <affiliation>Koc Univ, Dept Elect &amp; Elect Engn, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozber, Natali</creatorName>
      <givenName>Natali</givenName>
      <familyName>Ozber</familyName>
      <affiliation>Koc Univ, Dept Chem &amp; Biol Engn, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nargul, Sezin</creatorName>
      <givenName>Sezin</givenName>
      <familyName>Nargul</familyName>
      <affiliation>Koc Univ, Dept Chem &amp; Biol Engn, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yavuz, Serhat</creatorName>
      <givenName>Serhat</givenName>
      <familyName>Yavuz</familyName>
      <affiliation>Koc Univ, Dept Mech Engn, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kilic, M. Salih</creatorName>
      <givenName>M. Salih</givenName>
      <familyName>Kilic</familyName>
      <affiliation>Koc Univ, Dept Mech Engn, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kavakli, I. Halil</creatorName>
      <givenName>I. Halil</givenName>
      <familyName>Kavakli</familyName>
      <affiliation>Koc Univ, Dept Chem &amp; Biol Engn, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Urey, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Urey</familyName>
      <affiliation>Koc Univ, Dept Elect &amp; Elect Engn, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Alaca, B. Erdem</creatorName>
      <givenName>B. Erdem</givenName>
      <familyName>Alaca</familyName>
      <affiliation>Koc Univ, Dept Mech Engn, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Detection Of Human Kappa-Opioid Antibody Using Microresonators With Integrated Optical Readout</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2010</publicationYear>
  <dates>
    <date dateType="Issued">2010-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/25545</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.bios.2010.06.004</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Label-free detection of the interaction between hexahistidine-tagged human kappa-opioid receptor membrane protein and anti-His antibody is demonstrated in liquid by an optical microelectromechanical system utilizing electromagnetically actuated microresonators Shift in resonance frequency due to accretion of mass on the sensitive surface of microresonators is monitored via an integrated optical readout A frequency resolution of 2 Hz is obtained Together with a sensitivity of 7 ppm/(ng/ml)) this leads to a minimum detectable antibody concentration of 57 ng/ml for a 50-kHz device The measurement principle is shown to impart immunity to environmental noise, facilitate operation in liquid media and bring about the prospect for further miniaturization of actuator and readout leading to a portable biochemical sensor (C) 2010 Elsevier B V All rights reserved.</description>
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