1 Ocak 2022 Dergi makalesi Açık Erişim

Barakat, Sarah; Berksoz, Melike; Zahedimaram, Pegah; Piepoli, Sofia; Erman, Batu

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/254871</identifier>
  <creators>
    <creator>
      <creatorName>Barakat, Sarah</creatorName>
      <givenName>Sarah</givenName>
      <familyName>Barakat</familyName>
      <affiliation>Sabanci Univ, Fac Engn &amp; Nat Sci, TR-34956 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Berksoz, Melike</creatorName>
      <givenName>Melike</givenName>
      <familyName>Berksoz</familyName>
      <affiliation>Sabanci Univ, Fac Engn &amp; Nat Sci, TR-34956 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Zahedimaram, Pegah</creatorName>
      <givenName>Pegah</givenName>
      <familyName>Zahedimaram</familyName>
      <affiliation>Sabanci Univ, Fac Engn &amp; Nat Sci, TR-34956 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Piepoli, Sofia</creatorName>
      <givenName>Sofia</givenName>
      <familyName>Piepoli</familyName>
      <affiliation>Bogazici Univ, Fac Arts &amp; Sci, Dept Mol Biol &amp; Genet, TR-34342 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Erman, Batu</creatorName>
      <givenName>Batu</givenName>
      <familyName>Erman</familyName>
      <affiliation>Bogazici Univ, Fac Arts &amp; Sci, Dept Mol Biol &amp; Genet, TR-34342 Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Nanobodies As Molecular Imaging Probes</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2022</publicationYear>
  <dates>
    <date dateType="Issued">2022-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/254871</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.freeradbiomed.2022.02.031</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies (Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their desirable properties such as small size, high specificity, strong affinity, excellent stability, and modularity, nanobodies are on their way to overtake conventional antibodies in terms of popularity. To date, a broad range of nanobodies have been generated against different molecular targets with applications spanning basic research, diagnostics, and therapeutics. In the field of molecular imaging, nanobody-based probes have emerged as a powerful tool. Radioactive or fluorescently labeled nanobodies are now used to detect and track many targets in different biological systems using imaging techniques. In this review, we provide an overview of the use of nanobodies as molecular probes. Additionally, we discuss current techniques for the generation, conjugation, and intracellular delivery of nanobodies.</description>
  </descriptions>
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