1 Ocak 2022 Dergi makalesi Açık Erişim

Cavusoglu, Cengiz; Cogulu, Muhsin Ozgur; Durmaz, Asude; Cengisiz, Zehra; Yilmaz, Fethiye Ferda; Tasbakan, Mehmet Sezai; Tasbakan, Meltem; Gunduz, Cumhur; Bicmen, Can; Karaman, Onur; Taslidere, Hasan; Akin, Haluk; Akarca, Tulay; Dereli, Sevket

JSON-LD (schema.org)

{
  "@context": "https://schema.org/", 
  "@id": 254635, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Med, Dept Med Microbiol, Izmir, Turkey", 
      "name": "Cavusoglu, Cengiz"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Med, Dept Pediat, Izmir, Turkey", 
      "name": "Cogulu, Muhsin Ozgur"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Med, Dept Med Genet, Izmir, Turkey", 
      "name": "Durmaz, Asude"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Med, Dept Med Genet, Izmir, Turkey", 
      "name": "Cengisiz, Zehra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Pharm, Dept Pharmaceut Microbiol, Izmir, Turkey", 
      "name": "Yilmaz, Fethiye Ferda"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Med, Dept Chest Dis, Izmir, Turkey", 
      "name": "Tasbakan, Mehmet Sezai"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey", 
      "name": "Tasbakan, Meltem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Med, Dept Med Biol, Izmir, Turkey", 
      "name": "Gunduz, Cumhur"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Hlth Sci, Dr Suat Seren Chest Dis & Surg Training & Res Hos, Clin Microbiol Lab, Izmir, Turkey", 
      "name": "Bicmen, Can"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Hlth Sci, Dr Suat Seren Chest Dis & Surg Training & Res Hos, Clin Chest Dis, Izmir, Turkey", 
      "name": "Karaman, Onur"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Haseki Training & Res Hosp, Dept Med Genet, Dept Hlth Sci, Istanbul, Turkey", 
      "name": "Taslidere, Hasan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Med, Dept Med Genet, Izmir, Turkey", 
      "name": "Akin, Haluk"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Hlth Sci, Dr Suat Seren Chest Dis & Surg Training & Res Hos, Clin Chest Dis, Izmir, Turkey", 
      "name": "Akarca, Tulay"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Hlth Sci, Dr Suat Seren Chest Dis & Surg Training & Res Hos, Clin Chest Dis, Izmir, Turkey", 
      "name": "Dereli, Sevket"
    }
  ], 
  "datePublished": "2022-01-01", 
  "description": "Background/aim: In tuberculsosis (TB), miRNA has been used as a biomarker to distinguish between healthy individuals and TB patients. The aim of this study was to investigate (i) the association of the miRNA and cytokine expression levels, the course of tuberculosis infection, clinical forms and response to treatment, and (ii) the effects of genotypic features of bacteria on the course of tuberculosis and the relationship between miRNA and cytokine expressions and bacterial genotypes. Materials and methods: A total of 200 cases (100: culture positive active tuberculosis, 50: quantiferon positive latent tuberculosis infection and 50: quantiferon negative healthy controls) were included in the study. For the tuberculosis group at the time of admission and after treatment, for the latent tuberculosis infection and healthy control groups at the time of admission, miRNA and cytokine expressions were determined. Genotyping of M.tuberculosis isolates was performed by spoligotyping method. Results: While, in the comparison of miRNA expressions between the pretreatment patient group and the healthy control group, there was a statistically significant decrease in the expression of miR-454-3p, miR-15a-5p, miR-590-5p, miR-381, and miR-449a in the Pulmonary TB group, there was no significant change in miRNA expression in extrapulmonary TB patients. When the cytokine expressions of the patient group and the healthy control group were compared before treatment, the expressions of all cytokines in the patient group decreased. However, the only cytokine that showed a significantly lower expression was IL12A in PTB patients. Conclusion: There is no significant relationship between the clinical course of the disease, cytokine and miRNA expression, and the genotype of the bacteria.", 
  "headline": "Investigation of miRNA and cytokine expressions in latent tuberculosis infection and active tuberculosis", 
  "identifier": 254635, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Investigation of miRNA and cytokine expressions in latent tuberculosis infection and active tuberculosis", 
  "url": "https://aperta.ulakbim.gov.tr/record/254635"
}