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Adrenomedullin worsens skin necrosis in rats subjected to vincristine-induced extravasation

Kesik, V.; Kurt, B.; Tunc, T.; Karslioglu, Y.; Citak, E. C.; Kismet, E.; Koseoglu, V.


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/25445</identifier>
  <creators>
    <creator>
      <creatorName>Kesik, V.</creatorName>
      <givenName>V.</givenName>
      <familyName>Kesik</familyName>
      <affiliation>Gulhane Mil Med Fac, Sch Med, Dept Pediat Oncol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kurt, B.</creatorName>
      <givenName>B.</givenName>
      <familyName>Kurt</familyName>
      <affiliation>Gulhane Mil Med Fac, Sch Med, Dept Pathol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tunc, T.</creatorName>
      <givenName>T.</givenName>
      <familyName>Tunc</familyName>
      <affiliation>Gulhane Mil Med Fac, Sch Med, Dept Pediat, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karslioglu, Y.</creatorName>
      <givenName>Y.</givenName>
      <familyName>Karslioglu</familyName>
      <affiliation>Gulhane Mil Med Fac, Sch Med, Dept Pathol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Citak, E. C.</creatorName>
      <givenName>E. C.</givenName>
      <familyName>Citak</familyName>
      <affiliation>Gulhane Mil Med Fac, Sch Med, Dept Pediat Oncol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kismet, E.</creatorName>
      <givenName>E.</givenName>
      <familyName>Kismet</familyName>
      <affiliation>Gulhane Mil Med Fac, Sch Med, Dept Pediat Oncol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Koseoglu, V.</creatorName>
      <givenName>V.</givenName>
      <familyName>Koseoglu</familyName>
      <affiliation>Gulhane Mil Med Fac, Sch Med, Dept Pediat Oncol, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Adrenomedullin Worsens Skin Necrosis In Rats Subjected To Vincristine-Induced Extravasation</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2010</publicationYear>
  <dates>
    <date dateType="Issued">2010-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/25445</alternateIdentifier>
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  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1111/j.1365-2230.2010.03803.x</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background. Extravasation of vesiccant drugs such as vinca alkaloids causes severe injury, which may range from erythema to skin necrosis or ulceration. The skin necrosis may not be fully evident until several weeks or months after the initial damage, and may require surgical intervention. The main treatments for vincristine extravasation are hyaluronidase injection and topical warming, and the aim of treatment is to increase the clearance of the drug from the extravasation site.</description>
  </descriptions>
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