1 Ocak 2022 Dergi makalesi Açık Erişim

Atabay, Nihal; Sarhsik, Ayse Merih; Karavana, Sinem Yaprak; Rencber, Seda

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    <subfield code="a">Acne vulgaris is the most common dermatologic disorder, affecting approximately 85% of individuals, especially during adolescence. In this study, a plaster design was developed to support acne vulgaris treatment by using microsponge technology. To achieve this purpose, the microsponges containing benzoyl peroxide (BPO) were prepared by the quasi emulsion solvent diffusion method, and the obtained microparticles were examined in terms of surface morphology, particle size distribution, and encapsulation efficiency (EE). Fourier transform infrared and Brunauer-Emmett-Teller analyses were also performed. The microsponges were spherical in shape and around 110 mu m in diameter. The EE and drug loading from the microsponge powder were found to be 60.879% and 38.929%, respectively. The optimum microsponge formulation was selected and applied onto textile material with a spraying technique by using acrylic binder and hydroxypropyl methylcellulose. The presence of BPO-loaded microsponges on the fabric surface was proved by scanning electron microscopy analyses. The EE of BPO from the fabric samples was found to be 84.193%. The release properties of microsponges and treated textile material were also investigated. No burst effect has been observed, indicating that BPO was homogeneously dispersed in the microsponge. With the in vitro BPO release from the fabric sample after 3 hours, the release rate of formulation was found to be very low (approximately 10%). This study presents a new approach to the use of microsponges in the textile field.</subfield>
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    <subfield code="a">Atabay, Nihal</subfield>
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    <subfield code="a">A New Alternative for Acne Treatment: Plaster Containing Benzoyl Peroxide-Loaded Microsponges</subfield>
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