1 Ocak 2021 Dergi makalesi Açık Erişim

Turan, Raife Dilek; Tastan, Cihan; Kancagi, Derya Dilek; Yurtsever, Bulut; Karakus, Gozde Sir; Ozer, Samed; Abanuz, Selen; Cakirsoy, Didem; Tumentemur, Gamze; Demir, Sevda; Seyis, Utku; Kuzay, Recai; Elek, Muhammer; Kocaoglu, Miyase Ezgi; Ertop, Gurcan; Arbak, Serap; Elmas, Merve Acikel; Hemsinlioglu, Cansu; Ng, Ozden Hatirnaz; Akyoney, Sezer; Akyoney, Sezer

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/239638</identifier>
  <creators>
    <creator>
      <creatorName>Turan, Raife Dilek</creatorName>
      <givenName>Raife Dilek</givenName>
      <familyName>Turan</familyName>
    </creator>
    <creator>
      <creatorName>Tastan, Cihan</creatorName>
      <givenName>Cihan</givenName>
      <familyName>Tastan</familyName>
    </creator>
    <creator>
      <creatorName>Kancagi, Derya Dilek</creatorName>
      <givenName>Derya Dilek</givenName>
      <familyName>Kancagi</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yurtsever, Bulut</creatorName>
      <givenName>Bulut</givenName>
      <familyName>Yurtsever</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karakus, Gozde Sir</creatorName>
      <givenName>Gozde Sir</givenName>
      <familyName>Karakus</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozer, Samed</creatorName>
      <givenName>Samed</givenName>
      <familyName>Ozer</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Anim Applicat &amp; Res Ctr, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Abanuz, Selen</creatorName>
      <givenName>Selen</givenName>
      <familyName>Abanuz</familyName>
    </creator>
    <creator>
      <creatorName>Cakirsoy, Didem</creatorName>
      <givenName>Didem</givenName>
      <familyName>Cakirsoy</familyName>
    </creator>
    <creator>
      <creatorName>Tumentemur, Gamze</creatorName>
      <givenName>Gamze</givenName>
      <familyName>Tumentemur</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Vocat Sch Hlth Serv, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Demir, Sevda</creatorName>
      <givenName>Sevda</givenName>
      <familyName>Demir</familyName>
      <affiliation>Yeditepe Univ, Genet &amp; Bioengn Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Seyis, Utku</creatorName>
      <givenName>Utku</givenName>
      <familyName>Seyis</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kuzay, Recai</creatorName>
      <givenName>Recai</givenName>
      <familyName>Kuzay</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
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      <creatorName>Elek, Muhammer</creatorName>
      <givenName>Muhammer</givenName>
      <familyName>Elek</familyName>
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      <creatorName>Kocaoglu, Miyase Ezgi</creatorName>
      <givenName>Miyase Ezgi</givenName>
      <familyName>Kocaoglu</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
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    <creator>
      <creatorName>Ertop, Gurcan</creatorName>
      <givenName>Gurcan</givenName>
      <familyName>Ertop</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Vocat Sch Hlth Serv, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Arbak, Serap</creatorName>
      <givenName>Serap</givenName>
      <familyName>Arbak</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Histol &amp; Embryol Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Elmas, Merve Acikel</creatorName>
      <givenName>Merve Acikel</givenName>
      <familyName>Elmas</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Histol &amp; Embryol Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hemsinlioglu, Cansu</creatorName>
      <givenName>Cansu</givenName>
      <familyName>Hemsinlioglu</familyName>
      <affiliation>Acibadem Labcell Cellular Therapy Lab, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ng, Ozden Hatirnaz</creatorName>
      <givenName>Ozden Hatirnaz</givenName>
      <familyName>Ng</familyName>
      <affiliation>Acibadem Mehmet Ali Aydinlar Univ, Med Biol Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akyoney, Sezer</creatorName>
      <givenName>Sezer</givenName>
      <familyName>Akyoney</familyName>
    </creator>
    <creator>
      <creatorName>Akyoney, Sezer</creatorName>
      <givenName>Sezer</givenName>
      <familyName>Akyoney</familyName>
    </creator>
  </creators>
  <titles>
    <title>Gamma-Irradiated Sars-Cov-2 Vaccine Candidate, Ozg-38.61.3, Confers Protection From Sars-Cov-2 Challenge In Human Aceii-Transgenic Mice</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/239638</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1038/s41598-021-95086-4</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The SARS-CoV-2 virus caused the most severe pandemic around the world, and vaccine development for urgent use became a crucial issue. Inactivated virus formulated vaccines such as Hepatitis A and smallpox proved to be reliable approaches for immunization for prolonged periods. In this study, a gamma-irradiated inactivated virus vaccine does not require an extra purification process, unlike the chemically inactivated vaccines. Hence, the novelty of our vaccine candidate (OZG-38.61.3) is that it is a non-adjuvant added, gamma-irradiated, and intradermally applied inactive viral vaccine. Efficiency and safety dose (either 10(13) or 10(14) viral RNA copy per dose) of OZG-38.61.3 was initially determined in BALB/c mice. This was followed by testing the immunogenicity and protective efficacy of the vaccine. Human ACE2-encoding transgenic mice were immunized and then infected with the SARS-CoV-2 virus for the challenge test. This study shows that vaccinated mice have lowered SARS-CoV-2 viral RNA copy numbers both in oropharyngeal specimens and in the histological analysis of the lung tissues along with humoral and cellular immune responses, including the neutralizing antibodies similar to those shown in BALB/c mice without substantial toxicity. Subsequently, plans are being made for the commencement of Phase 1 clinical trial of the OZG-38.61.3 vaccine for the COVID-19 pandemic.</description>
  </descriptions>
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