1 Ocak 2021 Dergi makalesi Açık Erişim

Kantar, Cihan; Baltas, Nimet; Karaoglu, Sengul Alpay; Sasmaz, Selami

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    <subfield code="a">New Potential Monotherapeutic Candidates for Helicobacter pylori: Some Pyridinazo Compounds Having Both Urease Enzyme Inhibition and Anti-Helicobacter pylori Effectiveness</subfield>
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    <subfield code="a">To contribute to the monotherapeutic approach to Helicobacter pylori, some new pyridinazo compounds containing natural phenols such as eugenol and guaiacol were synthesized and their antioxidant capacities, urease enzyme inhibition and anti-Helicobacter pylori effect were investigated. This monotherapeutic approach suggests that a single synthetic drug with both a strong urease enzyme inhibitor and effective antibiotic properties can be used to treat Helicobacter pylori infection As expected, all newly obtained pyridinazo compounds have been found to have both urease enzyme inhibitor properties and anti-Helicobacter pylori activity.</subfield>
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