1 Ocak 2021 Dergi makalesi Açık Erişim

Dincel, Efe Dogukan; Hasbal-Celikok, Gozde; Yilmaz-Ozden, Tugba; Ulusoy-Guzeldemirci, Nuray

Citation Style Language JSON

{
  "DOI": "10.1016/j.molstruc.2021.131260", 
  "abstract": "Inhibiting the degradation of carbohydrates into glucose is considered to be an effective treatment for type 2 diabetes mellitus. Herein, a series of novel thiosemicarbazide and 1,2,4-triazole-3-thione derivatives of imidazo[2,1-b]thiazole were synthesized and evaluated for their alpha-glucosidase inhibitory activity. Compound 5c (IC50: 4.54 +/- 0.19 mu M) was found approximately 47 times more active than Acarbose (IC50: 214.71 +/- 8.34 mu M). In addition to the in vitro analysis, molecular docking studies were employed to explore the possible binding interactions of the title compounds. Structure-activity relationships, as well as virtual ADME studies, were carried out and a relationship between biological, electronic, and physicochemical qualifications of the target compounds was determined. Consequently, our studies indicated that these imidazo[2,1-b]thiazole derivatives possess the potential of being a novel class of alpha-glucosidase inhibitors. (C) 2021 Elsevier B.V. All rights reserved.", 
  "author": [
    {
      "family": "Dincel", 
      "given": " Efe Dogukan"
    }, 
    {
      "family": "Hasbal-Celikok", 
      "given": " Gozde"
    }, 
    {
      "family": "Yilmaz-Ozden", 
      "given": " Tugba"
    }, 
    {
      "family": "Ulusoy-Guzeldemirci", 
      "given": " Nuray"
    }
  ], 
  "container_title": "JOURNAL OF MOLECULAR STRUCTURE", 
  "id": "239134", 
  "issued": {
    "date-parts": [
      [
        2021, 
        1, 
        1
      ]
    ]
  }, 
  "title": "Design, biological evaluation, molecular docking study and in silico ADME prediction of novel imidazo[2,1-b]thiazole derivatives as a novel class of alpha-glucosidase inhibitors", 
  "type": "article-journal", 
  "volume": "1245"
}