1 Ocak 2021 Dergi makalesi Açık Erişim

Kasapgil, Esra; Badv, Maryam; Cantu, Claudia Alonso; Rahmani, Sara; Erbil, H. Yildirim; Sakir, Ilke Anac; Weitz, Jeffrey, I; Hosseini-Doust, Zeinab; Didar, Tohid F.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/238890</identifier>
  <creators>
    <creator>
      <creatorName>Kasapgil, Esra</creatorName>
      <givenName>Esra</givenName>
      <familyName>Kasapgil</familyName>
    </creator>
    <creator>
      <creatorName>Badv, Maryam</creatorName>
      <givenName>Maryam</givenName>
      <familyName>Badv</familyName>
    </creator>
    <creator>
      <creatorName>Cantu, Claudia Alonso</creatorName>
      <givenName>Claudia Alonso</givenName>
      <familyName>Cantu</familyName>
      <affiliation>McMaster Univ, Dept Chem Engn, Hamilton, ON L8S 4L8, Canada</affiliation>
    </creator>
    <creator>
      <creatorName>Rahmani, Sara</creatorName>
      <givenName>Sara</givenName>
      <familyName>Rahmani</familyName>
      <affiliation>McMaster Univ, Sch Biomed Engn, Hamilton, ON L8S 4L8, Canada</affiliation>
    </creator>
    <creator>
      <creatorName>Erbil, H. Yildirim</creatorName>
      <givenName>H. Yildirim</givenName>
      <familyName>Erbil</familyName>
      <affiliation>Gebze Tech Univ, Dept Chem Engn, TR-41400 Gebze, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sakir, Ilke Anac</creatorName>
      <givenName>Ilke Anac</givenName>
      <familyName>Sakir</familyName>
      <affiliation>Gebze Tech Univ, Dept Mat Sci &amp; Engn, TR-41400 Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Weitz, Jeffrey, I</creatorName>
    </creator>
    <creator>
      <creatorName>Hosseini-Doust, Zeinab</creatorName>
      <givenName>Zeinab</givenName>
      <familyName>Hosseini-Doust</familyName>
    </creator>
    <creator>
      <creatorName>Didar, Tohid F.</creatorName>
      <givenName>Tohid F.</givenName>
      <familyName>Didar</familyName>
    </creator>
  </creators>
  <titles>
    <title>Polysiloxane Nanofilaments Infused With Silicone Oil Prevent Bacterial Adhesion And Suppress Thrombosis On Intranasal Splints</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/238890</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1021/acsbiomaterials.0c01487</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Like all biofluid-contacting medical devices, intranasal splints are highly prone to bacterial adhesion and clot formation. Despite their widespread use and the numerous complications associated with infected splints, limited success has been achieved in advancing their safety and surface biocompatibility, and, to date, no surface-coating strategy has been proposed to simultaneously enhance the antithrombogenicity and bacterial repellency of intranasal splints. Herein, we report an efficient, highly stable lubricant-infused coating for intranasal splints to render their surfaces antithrombogenic and repellent toward bacterial cells. Lubricant-infused intranasal splints were prepared by creating superhydrophobic polysiloxane nanofilament (PSnF) coatings using surface-initiated polymerization of n-propyltrichlorosilane (n-PTCS) and further infiltrating them with a silicone oil lubricant. Compared with commercially available intranasal splints, lubricant-infused, PSnF-coated splints significantly attenuated plasma and blood clot formation and prevented bacterial adhesion and biofilm formation for up to 7 days, the typical duration for which intranasal splints are kept. We further demonstrated that the performance of our engineered biointerface is independent of the underlying substrate and could be used to enhance the hemocompatibility and repellency properties of other medical implants such as medical-grade catheters.</description>
  </descriptions>
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