1 Ocak 2021 Dergi makalesi Açık Erişim

Romano, F.; Muradoglu, M.; Fujioka, H.; Grotberg, J. B.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/238866</identifier>
  <creators>
    <creator>
      <creatorName>Romano, F.</creatorName>
      <givenName>F.</givenName>
      <familyName>Romano</familyName>
      <affiliation>Univ Lille, CNRS, Arts &amp; Metiers Inst Technol, Centrale Lille,ONERA,UMR 9014,LMFL Lab Mecan Flui, F-59000 Lille, France</affiliation>
    </creator>
    <creator>
      <creatorName>Muradoglu, M.</creatorName>
      <givenName>M.</givenName>
      <familyName>Muradoglu</familyName>
      <affiliation>Koc Univ, Dept Mech Engn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Fujioka, H.</creatorName>
      <givenName>H.</givenName>
      <familyName>Fujioka</familyName>
      <affiliation>Tulane Univ, Ctr Computat Sci, New Orleans, LA 70118 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Grotberg, J. B.</creatorName>
      <givenName>J. B.</givenName>
      <familyName>Grotberg</familyName>
      <affiliation>Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Effect Of Viscoelasticit Y In An Airway Closure Model</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/238866</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1017/jfm.2020.1162</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The closure of a human lung airway is modelled as a pipe coated internally with a liquid that takes into account the viscoelastic properties of mucus. For a thick-enough coating, the Plateau-Rayleigh instability blocks the airway by the creation of a liquid plug, and the preclosure phase is dominated by the Newtonian behaviour of the liquid. Our previous study with a Newtonian-liquid model demonstrated that the bifrontal plug growth consequent to airway closure induces a high level of stress and stress gradients on the airway wall, which is large enough to damage the epithelial cells, causing sublethal or lethal responses. In this study, we explore the effect of the viscoelastic properties of mucus by means of the Oldroyd-B and FENE-CR model. Viscoelasticity is shown to be very relevant in the postcoalescence process, introducing a second peak of the wall shear stresses. This second peak is related to an elastic instability due to the presence of the polymeric extra stresses. For high-enough Weissenberg and Laplace numbers, this second shear stress peak is as severe as the first one. Consequently, a second lethal or sublethal response of the epithelial cells is induced.</description>
  </descriptions>
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