1 Ocak 2021 Dergi makalesi Açık Erişim

Durgun, Mustafa; Zengin, Gulay; Zengin, Huseyin; Koyuncu, Ismail; Turkoglu, Seda; Sonmez, Hasan; Kuru, Ali

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  <identifier identifierType="DOI">10.48623/aperta.238794</identifier>
  <creators>
    <creator>
      <creatorName>Durgun, Mustafa</creatorName>
      <givenName>Mustafa</givenName>
      <familyName>Durgun</familyName>
      <affiliation>Harran Univ, Fac Arts &amp; Sci, Dept Chem, TR-63290 Sanliurfa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Zengin, Gulay</creatorName>
      <givenName>Gulay</givenName>
      <familyName>Zengin</familyName>
      <affiliation>Gaziantep Univ, Fac Arts &amp; Sci, Dept Chem, TR-27310 Gaziantep, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Zengin, Huseyin</creatorName>
      <givenName>Huseyin</givenName>
      <familyName>Zengin</familyName>
      <affiliation>Gaziantep Univ, Fac Arts &amp; Sci, Dept Chem, TR-27310 Gaziantep, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Koyuncu, Ismail</creatorName>
      <givenName>Ismail</givenName>
      <familyName>Koyuncu</familyName>
      <affiliation>Harran Univ, Fac Med, Dept Biochem, TR-63300 Sanliurfa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Turkoglu, Seda</creatorName>
      <givenName>Seda</givenName>
      <familyName>Turkoglu</familyName>
      <affiliation>Harran Univ, Fac Arts &amp; Sci, Dept Chem, TR-63290 Sanliurfa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sonmez, Hasan</creatorName>
      <givenName>Hasan</givenName>
      <familyName>Sonmez</familyName>
      <affiliation>Harran Univ, Fac Arts &amp; Sci, Dept Chem, TR-63290 Sanliurfa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kuru, Ali</creatorName>
      <givenName>Ali</givenName>
      <familyName>Kuru</familyName>
      <affiliation>Sakarya Univ, Fac Arts &amp; Sci, Dept Chem, TR-54187 Sakarya, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesis, Characterization, Cytotoxicity Evaluation And Physicochemical Properties Of Some Novel N-4-Substituted Aminobenzenesulfonamides</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/238794</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.48623/aperta.238793</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Several N-4-substituted aminobenzenesulfonamides derivatives have been synthesized and structural analyses have been carried out using FT-IR, UV-Vis, H-1 and C-13 NMR, LC-MS-MS and elemental analyses. Photoluminescence and physicochemical properties have also been conducted. Two 4-aminobenzenesulfonamides have been treated with 2-bromopropionyl bromide in pyridine to give their respective bromo substituted aminobenzenesulfonamides as intermediates. Subsequent reactions with morpholino-, thiomorpholino- and piperazine amines have yielded novel aminobenzenesulfonamide derivatives. As it is well known that CA IX and CA XII enzymes play an active role in attacking various cancerous conditions, studies presented in this study target these enzymes with in vitro cytotoxicity studies being performed on the compounds synthesized. The target compounds have been found to be active against some cancerous cells, with mimimal effects on normal cells. The physicochemical data reveal interesting synergistic effects controlling cytotoxicities, where the lipophilicity and polarity combinations play important roles on the eventual observed cytotoxicities. Further, the electronegativity and availability of the electrons of the heteroatoms of the synthesized compounds appear to have an effect on cancer cell cytotoxicities.</description>
  </descriptions>
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