1 Ocak 2021 Dergi makalesi Açık Erişim

Goger, Gamze; Yavas, Irem; Yur, Suleyman; Kose, Yavuz Bulent; Ozek, Gulmira

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    "creators": [
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        "affiliation": "Trakya Univ, Fac Pharm, Dept Pharmacognosy, TR-22030 Edirne, Turkey", 
        "name": "Goger, Gamze"
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      {
        "affiliation": "Trakya Univ, Fac Pharm, TR-22030 Edirne, Turkey", 
        "name": "Yavas, Irem"
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      {
        "affiliation": "Anadolu Univ, Med Plant Drug & Sci Res Ctr AUBIBAM, TR-26470 Eskisehir, Turkey", 
        "name": "Yur, Suleyman"
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      {
        "affiliation": "Anadolu Univ, Fac Pharm, Dept Pharmaceut Bot, TR-26470 Eskisehir, Turkey", 
        "name": "Kose, Yavuz Bulent"
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      {
        "affiliation": "Anadolu Univ, Fac Pharm, Dept Pharmacognosy, TR-26470 Eskisehir, Turkey", 
        "name": "Ozek, Gulmira"
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    "description": "In this study, the volatiles were obtained from aerial parts of Tripleurospermum decipiens (Fisch & C.A.Mey) Bornm with microsteam distillation - solid phase microextraction (MSD-SMPE) technique. The fatty acids from T. decipiens were obtained by using the microextraction method with subsequent transesterification with boron trifluoride reagent. The chemical compositions of the volatiles and fatty acid methyl esters was analyzed by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC / MS) techniques. n-Hexane (TDH) and methanol (TDM) extracts of T. decipiens were investigated for acetylcholineterase (AChE), alpha-amylase enzyme inhibitions and antimicrobial activities. In vitro inhibition of AChE was monitored by using Ellman's chromogenic agent, and antidiabetic effects of the extracts were spectrophometrically evaluated by inhibition of porcine pancreatic alpha-amylase enzyme. Antimicrobial activities of the extracts were evaluated against Salmonella enterica ATCC 14028, Bacillus subtilis subsp spizizeni ATCC 6633, B. subtilis ATCC 19654, Staphylococcus aureus ATCC 6538, Klebsiella aerogenes ATCC 13048, Candida parapsilosis ATCC 22019 by microdilution method. In vitro.-amylase enzyme inhibitory activity was observed for methanol extract (55.6%) at 10 mg/mL. The highest AChE inhibition was recorded for n-hexane extract (58.8%) at concentration (10 mg/mL). The extracts were found to be effective against B. subtilis ATCC 19654, B. subtilis subsp spizizeni ATCC 6633, S. aureus ATCC 6538 and C. parapsilosis ATCC 22019.", 
    "doi": "10.29228/jrp.34", 
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    "journal": {
      "issue": "4", 
      "pages": "429-440", 
      "title": "JOURNAL OF RESEARCH IN PHARMACY", 
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      "title": "Dergi makalesi", 
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    "science_branches": [
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    "title": "Volatiles and fatty acid analyzes of Tripleurospermum decipiens (Fisch & C. A. Mey) Bornm and investigation of the extracts for antimicrobial and enzyme inhibitory activities"
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