1 Ocak 2021 Dergi makalesi Açık Erişim

Karoglu-Eravsar, Elif Tugce; Tuz-Sasik, Melek Umay; Adams, Michelle M.

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/235242</identifier>
  <creators>
    <creator>
      <creatorName>Karoglu-Eravsar, Elif Tugce</creatorName>
      <givenName>Elif Tugce</givenName>
      <familyName>Karoglu-Eravsar</familyName>
    </creator>
    <creator>
      <creatorName>Tuz-Sasik, Melek Umay</creatorName>
      <givenName>Melek Umay</givenName>
      <familyName>Tuz-Sasik</familyName>
    </creator>
    <creator>
      <creatorName>Adams, Michelle M.</creatorName>
      <givenName>Michelle M.</givenName>
      <familyName>Adams</familyName>
    </creator>
  </creators>
  <titles>
    <title>Short-Term Dietary Restriction Maintains Synaptic Plasticity Whereas Short-Term Overfeeding Alters Cellular Dynamics In The Aged Brain: Evidence From The Zebrafish Model Organism</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/235242</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.neurobiolaging.2021.06.010</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Increased caloric intake (OF) impairs quality of life causing comorbidities with other diseases and cog-nitive deficits, whereas dietary restriction (DR) increases healthspan by preventing age-related deteriora-tions. To understand the effects of these opposing dietary regimens on the cellular and synaptic dynamics during brain aging, the zebrafish model, which shows gradual aging like mammals, was utilized. Global changes in cellular and synaptic markers with respect to age and a 12 week dietary regimen of OF and DR demonstrated that aging reduces the levels of the glutamate receptor subunits, GLUR2/3, inhibitory synaptic clustering protein, GEP, synaptic vesicle protein, SYP, and early-differentiated neuronal marker, HuC. DR significantly elevates levels of glutamate receptor subunits, GLUR2/3, and NMDA clustering pro-tein, PSD95, levels, while OF subtly increases the level of the neuronal protein, DCAMKL1. These data suggest that decreased caloric intake within the context of aging has more robust effects on synapses than cellular proteins, whereas OF alters cellular dynamics. Thus, patterns like these should be taken into account for possible translation to human subjects. (c) 2021 Elsevier Inc. All rights reserved.</description>
  </descriptions>
</resource>