1 Ocak 2022 Dergi makalesi Açık Erişim

Kavakli, Ibrahim Halil; Gul, Seref; Turkay, Metin

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Identification of novel small molecules targeting core clock proteins to regulate circadian rhythm</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">CURRENT OPINION IN CHEMICAL ENGINEERING</subfield>
    <subfield code="v">35</subfield>
  </datafield>
  <controlfield tag="001">234378</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">The circadian rhythms are physiological, biochemical, and behavioral oscillations that cycle every 24 hours to anticipate the daily changes in the external environment. Disruption of the circadian clock in mammals results in increased susceptibility to different types of diseases such as metabolic, mood and sleep disorders and cancer. To this end, different approaches have been taken to find small molecules that have the potential to correct the disrupted circadian clock. In this review, we highlight the recent developments in identifying novel molecules that regulate the activities of the core clock proteins. Finally, we discuss virtual screening-based methods using the crystal structures of core clock proteins for the discovery of small molecules that regulate the circadian rhythm.</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Istanbul Univ, Fac Sci, Dept Biol, Biotechnol Div, TR-34134 Istanbul, Turkey</subfield>
    <subfield code="a">Gul, Seref</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Koc Univ, Dept Ind Engn, Istanbul, Turkey</subfield>
    <subfield code="a">Turkay, Metin</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="b">article</subfield>
    <subfield code="a">publication</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Kavakli, Ibrahim Halil</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2022-01-01</subfield>
  </datafield>
  <controlfield tag="005">20221007090123.0</controlfield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:aperta.ulakbim.gov.tr:234378</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:a5e93aed8b3f9258c72634a0420de142</subfield>
    <subfield code="s">192</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/234378/files/bib-6a1ceaa1-ab54-45be-8c42-960f3b6e93e9.txt</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
    <subfield code="a">Creative Commons Attribution</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1016/j.coche.2021.100730</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
</record>