1 Ocak 2021 Dergi makalesi Açık Erişim

Kasap, Nurhan; Celik, Velat; Isik, Sakine; Cennetoglu, Pakize; Kiykim, Ayca; Eltan, Sevgi Bilgic; Nain, Ercan; Ogulur, Ismail; Baser, Dilek; Akkelle, Emre; Celiksoy, Mehmet Halil; Kocamis, Burcu; Cipe, Funda Erol; Yucelten, Ayse Deniz; Karakoc-Aydiner, Elif; Ozen, Ahmet; Baris, Safa

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/233152</identifier>
  <creators>
    <creator>
      <creatorName>Kasap, Nurhan</creatorName>
      <givenName>Nurhan</givenName>
      <familyName>Kasap</familyName>
    </creator>
    <creator>
      <creatorName>Celik, Velat</creatorName>
      <givenName>Velat</givenName>
      <familyName>Celik</familyName>
      <affiliation>Trakya Univ, Fac Med Pediat Allergy &amp; Immunol, Edirne, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Isik, Sakine</creatorName>
      <givenName>Sakine</givenName>
      <familyName>Isik</familyName>
      <affiliation>Sureyyapasa Chest Dis &amp; Thorac Surg Training &amp; Re, Dept Pediat Pediat Allergy &amp; Immunol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cennetoglu, Pakize</creatorName>
      <givenName>Pakize</givenName>
      <familyName>Cennetoglu</familyName>
      <affiliation>Marmara Univ, Dept Pediat, Fac Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kiykim, Ayca</creatorName>
      <givenName>Ayca</givenName>
      <familyName>Kiykim</familyName>
    </creator>
    <creator>
      <creatorName>Eltan, Sevgi Bilgic</creatorName>
      <givenName>Sevgi Bilgic</givenName>
      <familyName>Eltan</familyName>
    </creator>
    <creator>
      <creatorName>Nain, Ercan</creatorName>
      <givenName>Ercan</givenName>
      <familyName>Nain</familyName>
    </creator>
    <creator>
      <creatorName>Ogulur, Ismail</creatorName>
      <givenName>Ismail</givenName>
      <familyName>Ogulur</familyName>
    </creator>
    <creator>
      <creatorName>Baser, Dilek</creatorName>
      <givenName>Dilek</givenName>
      <familyName>Baser</familyName>
    </creator>
    <creator>
      <creatorName>Akkelle, Emre</creatorName>
      <givenName>Emre</givenName>
      <familyName>Akkelle</familyName>
      <affiliation>Sancaktepe Training &amp; Res Hosp, Pediat Allergy &amp; Immunol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Celiksoy, Mehmet Halil</creatorName>
      <givenName>Mehmet Halil</givenName>
      <familyName>Celiksoy</familyName>
      <affiliation>Gaziosmanpasa Taksim Training &amp; Res Hosp, Pediat Allergy &amp; Immunol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kocamis, Burcu</creatorName>
      <givenName>Burcu</givenName>
      <familyName>Kocamis</familyName>
    </creator>
    <creator>
      <creatorName>Cipe, Funda Erol</creatorName>
      <givenName>Funda Erol</givenName>
      <familyName>Cipe</familyName>
      <affiliation>Istinye Univ, Fac Med Pediat Allergy &amp; Immunol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yucelten, Ayse Deniz</creatorName>
      <givenName>Ayse Deniz</givenName>
      <familyName>Yucelten</familyName>
      <affiliation>Marmara Univ, Dept Dermatol, Fac Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karakoc-Aydiner, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Karakoc-Aydiner</familyName>
    </creator>
    <creator>
      <creatorName>Ozen, Ahmet</creatorName>
      <givenName>Ahmet</givenName>
      <familyName>Ozen</familyName>
    </creator>
    <creator>
      <creatorName>Baris, Safa</creatorName>
      <givenName>Safa</givenName>
      <familyName>Baris</familyName>
    </creator>
  </creators>
  <titles>
    <title>A Set Of Clinical And Laboratory Markers Differentiates Hyper-Ige Syndrome From Severe Atopic Dermatitis</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/233152</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.clim.2020.108645</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Hyper-IgE syndrome (HIES) patients may share many features observed in severe atopic dermatitis (SAD), making a diagnostic dilemma for physicians. Determining clinical and laboratory markers that distinguish both disorders could provide early diagnosis and treatment. We analyzed patients (DOCK8 deficiency:14, STAT3-HIES:10, SAD:10) with early-onset SAD. Recurrent upper respiratory tract infection and pneumonia were significantly frequent in HIES than SAD patients. Characteristic facial appearance, retained primary teeth, skin abscess, newborn rash, and pneumatocele were more predictable for STAT3-HIES, while mucocutaneous candidiasis and Herpes infection were common in DOCK8 deficiency, which were unusual in SAD group. DOCK8-deficient patients had lower CD3(+) and CD4(+)T cells with a senescent phenotype that unique for this form of HIES. Both DOCK8 deficiency and STAT3-HIES patients exhibited reduced switched memory B cells compared to the SAD patients. These clinical and laboratory markers are helpful to differentiate HIES from SAD patients.</description>
  </descriptions>
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