1 Ocak 2021 Dergi makalesi Açık Erişim

Fernandez-Checa, Jose C.; Bagnaninchi, Pierre; Ye, Hui; Sancho-Bru, Pau; Falcon-Perez, Juan M.; Royo, Felix; Garcia-Ruiz, Carmen; Konu, Ozlen; Miranda, Joana; Lunov, Oleg; Dejneka, Alexandr; Elfick, Alistair; McDonald, Alison; Sullivan, Gareth J.; Aithal, Guruprasad P.; Isabel Lucena, M.; Andrade, Raul J.; Fromenty, Bernard; Kranendonk, Michel; Javier Cubero, Francisco; Javier Cubero, Francisco

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/232868</identifier>
  <creators>
    <creator>
      <creatorName>Fernandez-Checa, Jose C.</creatorName>
      <givenName>Jose C.</givenName>
      <familyName>Fernandez-Checa</familyName>
    </creator>
    <creator>
      <creatorName>Bagnaninchi, Pierre</creatorName>
      <givenName>Pierre</givenName>
      <familyName>Bagnaninchi</familyName>
    </creator>
    <creator>
      <creatorName>Ye, Hui</creatorName>
      <givenName>Hui</givenName>
      <familyName>Ye</familyName>
    </creator>
    <creator>
      <creatorName>Sancho-Bru, Pau</creatorName>
      <givenName>Pau</givenName>
      <familyName>Sancho-Bru</familyName>
    </creator>
    <creator>
      <creatorName>Falcon-Perez, Juan M.</creatorName>
      <givenName>Juan M.</givenName>
      <familyName>Falcon-Perez</familyName>
    </creator>
    <creator>
      <creatorName>Royo, Felix</creatorName>
      <givenName>Felix</givenName>
      <familyName>Royo</familyName>
      <affiliation>Basque Res &amp; Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Exosomes Lab, Derio 48160, Bizkaia, Spain</affiliation>
    </creator>
    <creator>
      <creatorName>Garcia-Ruiz, Carmen</creatorName>
      <givenName>Carmen</givenName>
      <familyName>Garcia-Ruiz</familyName>
    </creator>
    <creator>
      <creatorName>Konu, Ozlen</creatorName>
      <givenName>Ozlen</givenName>
      <familyName>Konu</familyName>
    </creator>
    <creator>
      <creatorName>Miranda, Joana</creatorName>
      <givenName>Joana</givenName>
      <familyName>Miranda</familyName>
      <affiliation>Univ Lisbon, Fac Pharm, Res Inst iMed iMedULisboa, P-1649003 Lisbon, Portugal</affiliation>
    </creator>
    <creator>
      <creatorName>Lunov, Oleg</creatorName>
      <givenName>Oleg</givenName>
      <familyName>Lunov</familyName>
      <affiliation>Czech Acad Sci, Inst Phys, Dept Opt &amp; Biophys Syst, Prague, Czech Republic</affiliation>
    </creator>
    <creator>
      <creatorName>Dejneka, Alexandr</creatorName>
      <givenName>Alexandr</givenName>
      <familyName>Dejneka</familyName>
      <affiliation>Czech Acad Sci, Inst Phys, Dept Opt &amp; Biophys Syst, Prague, Czech Republic</affiliation>
    </creator>
    <creator>
      <creatorName>Elfick, Alistair</creatorName>
      <givenName>Alistair</givenName>
      <familyName>Elfick</familyName>
      <affiliation>Univ Edinburgh, Sch Engn, Inst Bioengn, Edinburgh EH8 3DW, Midlothian, Scotland</affiliation>
    </creator>
    <creator>
      <creatorName>McDonald, Alison</creatorName>
      <givenName>Alison</givenName>
      <familyName>McDonald</familyName>
      <affiliation>Univ Edinburgh, Sch Engn, Inst Bioengn, Edinburgh EH8 3DW, Midlothian, Scotland</affiliation>
    </creator>
    <creator>
      <creatorName>Sullivan, Gareth J.</creatorName>
      <givenName>Gareth J.</givenName>
      <familyName>Sullivan</familyName>
    </creator>
    <creator>
      <creatorName>Aithal, Guruprasad P.</creatorName>
      <givenName>Guruprasad P.</givenName>
      <familyName>Aithal</familyName>
    </creator>
    <creator>
      <creatorName>Isabel Lucena, M.</creatorName>
      <givenName>M.</givenName>
      <familyName>Isabel Lucena</familyName>
    </creator>
    <creator>
      <creatorName>Andrade, Raul J.</creatorName>
      <givenName>Raul J.</givenName>
      <familyName>Andrade</familyName>
    </creator>
    <creator>
      <creatorName>Fromenty, Bernard</creatorName>
      <givenName>Bernard</givenName>
      <familyName>Fromenty</familyName>
      <affiliation>Univ Rennes, Inst NUMECAN Nutr Metab &amp; Canc UMR A 1341, INSERM, INRAE,UMR S 1241, F-35000 Rennes, France</affiliation>
    </creator>
    <creator>
      <creatorName>Kranendonk, Michel</creatorName>
      <givenName>Michel</givenName>
      <familyName>Kranendonk</familyName>
      <affiliation>Univ NOVA Lisboa, Fac Med Sci, NOVA Med Sch, Ctr Toxicogen &amp; Human Hlth ToxOm,Genet Oncol &amp; Hu, Lisbon, Portugal</affiliation>
    </creator>
    <creator>
      <creatorName>Javier Cubero, Francisco</creatorName>
      <givenName>Francisco</givenName>
      <familyName>Javier Cubero</familyName>
    </creator>
    <creator>
      <creatorName>Javier Cubero, Francisco</creatorName>
      <givenName>Francisco</givenName>
      <familyName>Javier Cubero</familyName>
    </creator>
  </creators>
  <titles>
    <title>Advanced Preclinical Models For Evaluation Of Drug-Induced Liver Injury - Consensus Statement By The European Drug-Induced Liver Injury Network [Pro-Euro-Dili-Net]</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/232868</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.jhep.2021.06.021</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Drug-induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies. Given the wide use of both prescribed and over the counter drugs, DILI has become a major health issue for which there is a pressing need to find novel and effective therapies. Although significant progress has been made in understanding the molecular mechanisms underlying DILI, our incomplete knowledge of its pathogenesis and inability to predict DILI is largely due to both discordance between human and animal DILI in preclinical drug development and a lack of models that faithfully recapitulate complex pathophysiological features of human DILI. This is exemplified by the hepatotoxicity of acetaminophen (APAP) overdose, a major cause of ALF because of its extensive worldwide use as an analgesic. Despite intensive efforts utilising current animal and in vitro models, the mechanisms involved in the hepatotoxicity of APAP are still not fully understood. In this expert Consensus Statement, which is endorsed by the European Drug-Induced Liver Injury Network, we aim to facilitate and outline clinically impactful discoveries by detailing the requirements for more realistic human-based systems to assess hepatotoxicity and guide future drug safety testing. We present novel insights and discuss major players in APAP pathophysiology, and describe emerging in vitro and in vivo pre-clinical models, as well as advanced imaging and in silico technologies, which may improve prediction of clinical outcomes of DILI. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.</description>
  </descriptions>
</resource>