1 Ocak 2021 Dergi makalesi Açık Erişim

Gundogdu, Ramazan; Erdogan, M. Kadir; Ditsiou, Angeliki; Spanswick, Victoria; Garcia-Gomez, Juan Jose; Hartley, John A.; Esashi, Fumiko; Hergovich, Alexander; Gomez, Valenti

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        "name": "Gundogdu, Ramazan"
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        "affiliation": "Bingol Univ, Dept Biol, TR-12000 Bingol, Turkey", 
        "name": "Erdogan, M. Kadir"
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      {
        "name": "Ditsiou, Angeliki"
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      {
        "affiliation": "UCL, UCL Canc Inst, London WC1E 6DD, England", 
        "name": "Spanswick, Victoria"
      }, 
      {
        "affiliation": "UCL, UCL Canc Inst, London WC1E 6DD, England", 
        "name": "Garcia-Gomez, Juan Jose"
      }, 
      {
        "affiliation": "UCL, UCL Canc Inst, London WC1E 6DD, England", 
        "name": "Hartley, John A."
      }, 
      {
        "affiliation": "Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England", 
        "name": "Esashi, Fumiko"
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      {
        "name": "Hergovich, Alexander"
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      {
        "name": "Gomez, Valenti"
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    "description": "Monopolar spindle-one binder (MOBs) proteins are evolutionarily conserved and contribute to various cellular signalling pathways. Recently, we reported that hMOB2 functions in preventing the accumulation of endogenous DNA damage and a subsequent p53/p21-dependent G1/S cell cycle arrest in untransformed cells. However, the question of how hMOB2 protects cells from endogenous DNA damage accumulation remained enigmatic. Here, we uncover hMOB2 as a regulator of double-strand break (DSB) repair by homologous recombination (HR). hMOB2 supports the phosphorylation and accumulation of the RAD51 recombinase on resected single-strand DNA (ssDNA) overhangs. Physiologically, hMOB2 expression supports cancer cell survival in response to DSBinducing anti-cancer compounds. Specifically, loss of hMOB2 renders ovarian and other cancer cells more vulnerable to FDA-approved PARP inhibitors. Reduced MOB2 expression correlates with increased overall survival in patients suffering from ovarian carcinoma. Taken together, our findings suggest that hMOB2 expression may serve as a candidate stratification biomarker of patients for HR-deficiency targeted cancer therapies, such as PARP inhibitor treatments.", 
    "doi": "10.1016/j.cellsig.2021.110106", 
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    "journal": {
      "title": "CELLULAR SIGNALLING", 
      "volume": "87"
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    "license": {
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    "publication_date": "2021-01-01", 
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    "science_branches": [
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    "title": "hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors"
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