1 Ocak 2021 Dergi makalesi Açık Erişim

Sudagidan, Mert; Yildiz, Gulsah; Onen, Selin; Al, Rabia; Temiz, S. Sevval Nur; Yurt, Mediha Nur Zafer; Tasbasi, Behiye Busra; Acar, Elif Esma; Coban, Aysen; Aydin, Ali; Dursun, Ali D.; Ozalp, Veli C.

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{
  "@context": "https://schema.org/", 
  "@id": 231822, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Konya Food & Agr Univ, Kit ARGEM R&D Ctr, TR-42080 Konya, Turkey", 
      "name": "Sudagidan, Mert"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Konya Food & Agr Univ, Kit ARGEM R&D Ctr, TR-42080 Konya, Turkey", 
      "name": "Yildiz, Gulsah"
    }, 
    {
      "@type": "Person", 
      "name": "Onen, Selin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Mugla Sitki Kocman Univ, Dept Mol Biol & Genet, TR-48000 Mugla, Turkey", 
      "name": "Al, Rabia"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Selcuk Univ, Dept Biol, TR-42130 Konya, Turkey", 
      "name": "Temiz, S. Sevval Nur"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Konya Food & Agr Univ, Kit ARGEM R&D Ctr, TR-42080 Konya, Turkey", 
      "name": "Yurt, Mediha Nur Zafer"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Konya Food & Agr Univ, Kit ARGEM R&D Ctr, TR-42080 Konya, Turkey", 
      "name": "Tasbasi, Behiye Busra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Konya Food & Agr Univ, Kit ARGEM R&D Ctr, TR-42080 Konya, Turkey", 
      "name": "Acar, Elif Esma"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Gedik Univ, Dept Gastron & Culinary Arts, TR-34876 Istanbul, Turkey", 
      "name": "Coban, Aysen"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Istanbul Univ Cerrahpasa, Fac Vet Med, Dept Food Hyg & Technol, Istanbul, Turkey", 
      "name": "Aydin, Ali"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Atilim Univ, Med Sch, Dept Physiol, TR-06830 Ankara, Turkey", 
      "name": "Dursun, Ali D."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Atilim Univ, Med Sch, Dept Biol, TR-06830 Ankara, Turkey", 
      "name": "Ozalp, Veli C."
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "Benzalkonium chloride (BAC) is a common ingredient of disinfectants used for industrial, medical, food safety and domestic applications. It is a common pollutant detected in surface and wastewaters to induce adverse effects on Human health as well as aquatic and terrestrial life forms. Since disinfectant use is essential in combatting against microorganisms, the best approach to reduce ecotoxicity level is to restrict BAC use. We report here that encapsulation of BAC in mesoporous silica nanoparticles can provide an efficient strategy for inhibition of mi-crobial activity with lower than usual concentrations of disinfectants. As a proof-of-concept, Listeria mono-cytogenes was evaluated for minimum inhibitory concentration (MIC) of nanomaterial encapsulated BAC. Aptamer molecular gate structures provided a specific targeting of the disinfectant to Listeria cells, leading to high BAC concentrations around bacterial cells, but significantly reduced amounts in total. This strategy allowed to inhibition of BAC resistant Listeria strains with 8 times less the usual disinfectant dose. BAC encapsulated and aptamer functionalized silica nanoparticles (AptBACNP) effectively killed only target bacteria L. monocytogenes, but not the non-target cells, Staphylococcus aureus or Escherichia coli. AptBACNP was not cytotoxic to Human cells as determined by in vitro viability assays.", 
  "headline": "Targeted mesoporous silica nanoparticles for improved inhibition of disinfectant resistant Listeria monocytogenes and lower environmental pollution", 
  "identifier": 231822, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Targeted mesoporous silica nanoparticles for improved inhibition of disinfectant resistant Listeria monocytogenes and lower environmental pollution", 
  "url": "https://aperta.ulakbim.gov.tr/record/231822"
}