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Increasing the packing density of assays in paper-based microfluidic devices

Dabbagh, Sajjad Rahmani; Becher, Elaina; Ghaderinezhad, Fariba; Havlucu, Hayati; Ozcan, Oguzhan; Ozkan, Mehmed; Yetisen, Ali Kemal; Tasoglu, Savas


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/231728</identifier>
  <creators>
    <creator>
      <creatorName>Dabbagh, Sajjad Rahmani</creatorName>
      <givenName>Sajjad Rahmani</givenName>
      <familyName>Dabbagh</familyName>
    </creator>
    <creator>
      <creatorName>Becher, Elaina</creatorName>
      <givenName>Elaina</givenName>
      <familyName>Becher</familyName>
      <affiliation>Univ Connecticut, Dept Biomed Engn, Storrs, CT 06269 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Ghaderinezhad, Fariba</creatorName>
      <givenName>Fariba</givenName>
      <familyName>Ghaderinezhad</familyName>
      <affiliation>Univ Connecticut, Dept Mech Engn, Storrs, CT 06269 USA</affiliation>
    </creator>
    <creator>
      <creatorName>Havlucu, Hayati</creatorName>
      <givenName>Hayati</givenName>
      <familyName>Havlucu</familyName>
      <affiliation>Koc Univ, Koc Univ Arcelik Res Ctr Creat Ind KUAR, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozcan, Oguzhan</creatorName>
      <givenName>Oguzhan</givenName>
      <familyName>Ozcan</familyName>
      <affiliation>Koc Univ, Koc Univ Arcelik Res Ctr Creat Ind KUAR, TR-34450 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozkan, Mehmed</creatorName>
      <givenName>Mehmed</givenName>
      <familyName>Ozkan</familyName>
      <affiliation>Bogazici Univ, Bogazici Inst Biomed Engn, TR-34684 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yetisen, Ali Kemal</creatorName>
      <givenName>Ali Kemal</givenName>
      <familyName>Yetisen</familyName>
      <affiliation>Imperial Coll London, Dept Chem Engn, London SW7 2AZ, England</affiliation>
    </creator>
    <creator>
      <creatorName>Tasoglu, Savas</creatorName>
      <givenName>Savas</givenName>
      <familyName>Tasoglu</familyName>
    </creator>
  </creators>
  <titles>
    <title>Increasing The Packing Density Of Assays In Paper-Based Microfluidic Devices</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2021</publicationYear>
  <dates>
    <date dateType="Issued">2021-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/231728</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1063/5.0042816</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Paper-based devices have a wide range of applications in point-of-care diagnostics, environmental analysis, and food monitoring. Paper-based devices can be deployed to resource-limited countries and remote settings in developed countries. Paper-based point-of-care devices can provide access to diagnostic assays without significant user training to perform the tests accurately and timely. The market penetration of paper-based assays requires decreased device fabrication costs, including larger packing density of assays (i.e., closely packed features) and minimization of assay reagents. In this review, we discuss fabrication methods that allow for increasing packing density and generating closely packed features in paper-based devices. To ensure that the paper-based device is low-cost, advanced fabrication methods have been developed for the mass production of closely packed assays. These emerging methods will enable minimizing the volume of required samples (e.g., liquid biopsies) and reagents in paper-based microfluidic devices.</description>
  </descriptions>
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