1 Ocak 2021 Dergi makalesi Açık Erişim

Kucukturkmen, Berrin; Oz, Umut Can; Toptas, Mete; Devrim, Burcu; Saka, Ongun Mehmet; Bilgili, Hasan; Deveci, Mehmet Salih; Unsal, Elif; Bozkir, Asuman

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Oz, Umut Can</subfield>
    <subfield code="u">Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Toptas, Mete</subfield>
    <subfield code="u">Bezmialem Univ, Fac Dent, Dept Periodontol, Istanbul, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Devrim, Burcu</subfield>
    <subfield code="u">Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Saka, Ongun Mehmet</subfield>
    <subfield code="u">Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Bilgili, Hasan</subfield>
    <subfield code="u">Ankara Univ, Fac Vet Med, Dept Surg, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Deveci, Mehmet Salih</subfield>
    <subfield code="u">Hlth Sci Univ, Gulhane Med Fac, Pathol Dept, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Unsal, Elif</subfield>
    <subfield code="u">Ankara Univ, Fac Dent, Dept Periodontol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Bozkir, Asuman</subfield>
    <subfield code="u">Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">JOURNAL OF PHARMACEUTICAL SCIENCES</subfield>
    <subfield code="v">110</subfield>
    <subfield code="n">9</subfield>
    <subfield code="c">3200-3207</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1016/j.xphs.2021.05.002</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Development of Zoledronic Acid Containing Biomaterials for Enhanced Guided Bone Regeneration</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Kucukturkmen, Berrin</subfield>
    <subfield code="u">Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:aperta.ulakbim.gov.tr:231508</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2021-01-01</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/231508/files/bib-9810f3eb-ba2a-4f53-8331-526d744b89dd.txt</subfield>
    <subfield code="z">md5:f7a2b005f37c91c5e1bbfacdc1d586b9</subfield>
    <subfield code="s">264</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <controlfield tag="005">20221007081101.0</controlfield>
  <controlfield tag="001">231508</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">In recent years, biomaterial-based treatments, also called guided bone regeneration (GBR), which aim to establish a bone regeneration site and prevent the migration of gingival connective tissue and / or peripheral epithelium through the defective area during periodontal surgical procedures have come to the fore. In this report, we have developed a nanoparticle bearing thermosensitive in situ gel formulation of Pluronic F127 and poly(D,L-lactic acid) based membrane to reveal their utilization at GBR by in-vivo applications. In addition, the encouragement of the bone formation in defect area via inhibition of osteoclastic activity is intended by fabrication these biodegradable biomaterials at a lowered Zoledronic Acid (ZA) dose. Both of the developed materials remained stable under specified stability conditions (25 degrees C, 6 months) and provided the extended release profile of ZA. The in-vivo efficacy of nanoparticle bearing in situ gel formulation, membrane formulation and simultaneous application for guided bone regeneration was investigated in New Zealand female rabbits with a critical size defect of 0.5  pound 0.5 cm in the tibia bone for eight weeks. Based on the histopathological findings, lamellar bone and primarily woven bone formations were observed after 8 weeks of post-implantation of both formulations, while fibrosis was detected only in the untreated group. Lamellar bone growth was remarkably achieved just four weeks after the simultaneous application of formulations. Consequently, the simultaneous application of ZA-membrane and ZA-nanoparticles loaded in-situ gel formulations offers enhanced and faster GBR therapy alternatives. (c) 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.</subfield>
  </datafield>
</record>