Dergi makalesi Açık Erişim
Senkardes, Sevil; Ture, Asli; Ekrek, Sedanur; Durak, Asim Tugrul; Abbak, Muruvvet; Cevik, Ozge; Kaskatepe, Banu; Kucukguzel, Ilkay; Kucukguzel, S. Guniz
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Novel 2,6-disubstituted pyridine hydrazones: Synthesis, anticancer activity, docking studies and effects on caspase-3-mediated apoptosis</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">JOURNAL OF MOLECULAR STRUCTURE</subfield> <subfield code="v">1223</subfield> </datafield> <controlfield tag="001">231364</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Novel pyridine-based dihydrazones (3a-l) were synthesized by the condensation of appropriate aldehydes and pyridine-2,6-dicarbohydrazide (2) which was obtained by the treatment of dimethyl pyridine-2,6-dicarboxylate (1) with hydrazine hydrate. Structures of all the synthesized compounds were supported by their FTIR, H-1 NMR, C-13 NMR and microanalytical data. The compounds were screened primarily for their antibacterial activities as well as anticancer activities. None of the synthesized compounds had important antibacterial activity. Among the compounds which were tested against human colon cancer cell line (HT-29), compounds 3f and 3k showed significant activity (IC50=6.78 mu M for compound 3f, IC50 = 8.88 mu M for compound 3k). In addition, compound 3g exhibited promising activity against Ishikawa human endometrial cancer cell line (ISH) with an IC50 value of 8.26 mu M. At 10 mu M, compounds 3f, 3k and 3g caused morphological changes of HT-29 and ISH cells and caspase-3 activation. In addition, these compounds were evaluated against NIH 3T3 mouse embriyonic fibroblast cell line and all synthesized compounds (3a-l) were found to be less toxic than paclitaxel. Moreover, possible inhibition mechanism of compound 3g was evaluated in silico against BRAF kinase enzyme. (C) 2020 Elsevier B.V. All rights reserved.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34668 Istanbul, Turkey</subfield> <subfield code="a">Ture, Asli</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Fac Pharm, Istanbul, Turkey</subfield> <subfield code="a">Ekrek, Sedanur</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Fac Pharm, Istanbul, Turkey</subfield> <subfield code="a">Durak, Asim Tugrul</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Adnan Menderes Univ, Sci Technol Res & Applicat Ctr, Aydin, Turkey</subfield> <subfield code="a">Abbak, Muruvvet</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Adnan Menderes Univ, Sch Med, Dept Biochem, Aydin, Turkey</subfield> <subfield code="a">Cevik, Ozge</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Ankara Univ, Fac Pharm, Dept Pharmaceut Microbiol, Ankara, Turkey</subfield> <subfield code="a">Kaskatepe, Banu</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34668 Istanbul, Turkey</subfield> <subfield code="a">Kucukguzel, Ilkay</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34668 Istanbul, Turkey</subfield> <subfield code="a">Kucukguzel, S. Guniz</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34668 Istanbul, Turkey</subfield> <subfield code="a">Senkardes, Sevil</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2021-01-01</subfield> </datafield> <controlfield tag="005">20221007080633.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:aperta.ulakbim.gov.tr:231364</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:87dcf4f9334969cfa66e411bae258c68</subfield> <subfield code="s">305</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/231364/files/bib-4ece5a57-90a8-43a3-8227-7ba8f0dc825a.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1016/j.molstruc.2020.128962</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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