1 Ocak 2022 Dergi makalesi Açık Erişim

Cayan, Fatih; Tel-Cayan, Gulsen; Deveci, Ebru; Duru, Mehmet Emin; Turk, Mustafa

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    "creators": [
      {
        "affiliation": "Mugla Sitki Kocman Univ, Mugla Vocat Sch, Dept Chem & Chem Proc Technol, TR-48000 Mugla, Turkey", 
        "name": "Cayan, Fatih"
      }, 
      {
        "affiliation": "Mugla Sitki Kocman Univ, Mugla Vocat Sch, Dept Chem & Chem Proc Technol, TR-48000 Mugla, Turkey", 
        "name": "Tel-Cayan, Gulsen"
      }, 
      {
        "affiliation": "Konya Tech Univ, Tech Sci Vocat Sch, Chem & Chem Proc Technol Dept, TR-42250 Konya, Turkey", 
        "name": "Deveci, Ebru"
      }, 
      {
        "affiliation": "Mugla Sitki Kogman Univ, Fac Sci, Dept Chem, TR-48000 Mugla, Turkey", 
        "name": "Duru, Mehmet Emin"
      }, 
      {
        "affiliation": "Kirikkale Univ, Fac Engn & Architecture, Dept Bioengn, TR-71450 Kirikkale, Turkey", 
        "name": "Turk, Mustafa"
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    "description": "Mushrooms and truffles are attracting attention as a new generation of biotherapeutics. In the current study, isolation, phenolic and organic acid composition, and antioxidant, cytotoxic, anticholinesterase activities of truffle Reddellomyces parvulosporus were examined. Four known compounds (brassicasterol (1), ergosterol peroxide (2), fumaric acid (3) and mannitol (4)) were isolated with the combination of chromatographic techniques. Fumaric acid (54.74 +/- 0.85 mu g g(-1)) was found as the major compound by HPLC-DAD. All isolated compounds were bioassayed for antioxidant, cytotoxic, anticholinesterase, anti-tyrosinase, anti-urease, anti-alpha-glucosidase and anti-alpha-amylase activities. Compound 1 indicated notable cytotoxic activity on MCF-7 (IC50: 38.08 +/- 0.75 mu g mL(-1)) and compound 3 on H1299 (IC50: 62.37 +/- 0.75 mu g mL(-1)). Also, compounds 1 (84.55 +/- 1.14%) and 2 (84.90 +/- 0.10%) showed higher anti-urease activity than thiourea (78.57 +/- 0.22%), while compound 2 (66.31 +/- 0.08%) displayed near-standard anti-BChE activity. Also, being the first to emphasise the potential of R. parvulosporus as a natural food additive, this study evidenced its medicinal importance by revealing bioactive compounds and properties.", 
    "doi": "10.1111/ijfs.15190", 
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    "journal": {
      "issue": "3", 
      "pages": "1411-1419", 
      "title": "INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY", 
      "volume": "57"
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    "license": {
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    "publication_date": "2022-01-01", 
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      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
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    "science_branches": [
      "Di\u011fer"
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    "title": "A detailed study on multifaceted bioactivities of the extracts and isolated compounds from truffle Reddellomyces parvulosporus"
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