1 Ocak 2021 Dergi makalesi Açık Erişim

Arslan, Fatma Demet; Kocak, Ayse; Aydin, Cengiz; Pala, Emel Ebru; Oncel, Dilek; Diniz, Gulden; Kaya, Tayfun; Ugurlu, Levent; Degirmenci, Mustafa; Ozkan, Bulent; Soysal, Yasemin; Said, Harun Muayad

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    <subfield code="a">Evaluation of potential tumor markers that may predict neoadjuvant treatment efficiency in rectal cancer</subfield>
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    <subfield code="a">Objectives: The recurrence of rectal cancer or its resistance to neoadjuvant treatment develops due to the adaptation to hypoxia, apoptosis or autophagy. Survivin, one of the inhibitors of apoptosis; Beclin 1, which is a positive regulator in the autophagy pathway; and hypoxia-inducible factor-1 alpha (HIF-1 alpha) and carbonic anhydrase-9 (CA9), which are associated with tumor tissue hypoxia, may be related to resistance to treatment. Our aim was to evaluate the potential tumor markers that may help to monitor the response to neoadjuvant treatment in locally advanced rectal cancer (RC).</subfield>
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