1 Ocak 2021 Dergi makalesi Açık Erişim

Ceballos, Francisco C.; Gurun, Kanat; Altinisik, N. Ezgi; Gemici, Hasan Can; Karamurat, Cansu; Koptekin, Dilek; Vural, Kivilcim Basak; Mapelli, Igor; Saglican, Ekin; Surer, Elif; Erdal, Yilmaz Selim; Gotherstrom, Anders; Ozer, Fusun; Atakuman, Cigdem; Somel, Mehmet

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    "creators": [
      {
        "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
        "name": "Ceballos, Francisco C."
      }, 
      {
        "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
        "name": "Gurun, Kanat"
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      {
        "affiliation": "Hacettepe Univ, Dept Anthropol, Human G Lab, TR-06800 Ankara, Turkey", 
        "name": "Altinisik, N. Ezgi"
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      {
        "affiliation": "Middle East Tech Univ, Dept Settlement Archaeol, TR-06800 Ankara, Turkey", 
        "name": "Gemici, Hasan Can"
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      {
        "affiliation": "Middle East Tech Univ, Dept Settlement Archaeol, TR-06800 Ankara, Turkey", 
        "name": "Karamurat, Cansu"
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      {
        "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
        "name": "Koptekin, Dilek"
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      {
        "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
        "name": "Vural, Kivilcim Basak"
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      {
        "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
        "name": "Mapelli, Igor"
      }, 
      {
        "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
        "name": "Saglican, Ekin"
      }, 
      {
        "affiliation": "Middle East Tech Univ, Grad Sch Informat, Dept Modeling & Simulat, TR-06800 Ankara, Turkey", 
        "name": "Surer, Elif"
      }, 
      {
        "affiliation": "Hacettepe Univ, Dept Anthropol, Human G Lab, TR-06800 Ankara, Turkey", 
        "name": "Erdal, Yilmaz Selim"
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      {
        "name": "Gotherstrom, Anders"
      }, 
      {
        "affiliation": "Hacettepe Univ, Dept Anthropol, Human G Lab, TR-06800 Ankara, Turkey", 
        "name": "Ozer, Fusun"
      }, 
      {
        "affiliation": "Middle East Tech Univ, Dept Settlement Archaeol, TR-06800 Ankara, Turkey", 
        "name": "Atakuman, Cigdem"
      }, 
      {
        "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
        "name": "Somel, Mehmet"
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    ], 
    "description": "The history of human inbreeding is controversial.(1) In particular, how the development of sedentary and/or agricultural societies may have influenced overall inbreeding levels, relative to those of hunter-gatherer communities, is unclear.(2-5) Here, we present an approach for reliable estimation of runs of homozygosity (ROHs) in genomes with >= 3x mean sequence coverage across >1 million SNPs and apply this to 411 ancient Eurasian genomes from the last 15,000 years.(5-34) We show that the frequency of inbreeding, as measured by ROHs, has decreased over time. The strongest effect is associated with the Neolithic transition, but the trend has since continued, indicating a population size effect on inbreeding prevalence. We further show that most inbreeding in our historical sample can be attributed to small population size instead of consanguinity. Cases of high consanguinity were rare and only observed among members of farming societies in our sample. Despite the lack of evidence for common consanguinity in our ancient sample, consanguineous traditions are today prevalent in various modem-day Eurasian societies,(1, 35-37) suggesting that such practices may have become widespread within the last few millennia.", 
    "doi": "10.1016/j.cub.2021.06.027", 
    "has_grant": false, 
    "journal": {
      "issue": "17", 
      "pages": "3925-+", 
      "title": "CURRENT BIOLOGY", 
      "volume": "31"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2021-01-01", 
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      "title": "Dergi makalesi", 
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    "science_branches": [
      "Di\u011fer"
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    "title": "Human inbreeding has decreased in time through the Holocene"
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