1 Ocak 2021 Dergi makalesi Açık Erişim

Dogan, Elvan; Kisim, Asli; Bati-Ayaz, Gizem; Kubicek, Gregory J.; Pesen-Okvur, Devrim; Miri, Amir K.

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  "@id": 230310, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Rowan Univ, Dept Mech Engn, Glassboro, NJ 08028 USA", 
      "name": "Dogan, Elvan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Izmir Inst Technol, Dept Mol Biol & Genet, Gulbahce Kampusu, TR-35430 Izmir, Turkey", 
      "name": "Kisim, Asli"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Izmir Inst Technol, Biotechnol & Bioengn, Izmir, Turkey", 
      "name": "Bati-Ayaz, Gizem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "MD Anderson Canc Ctr Cooper, Dept Radiat Oncol, 2 Cooper Plaza, Camden, NJ 08103 USA", 
      "name": "Kubicek, Gregory J."
    }, 
    {
      "@type": "Person", 
      "name": "Pesen-Okvur, Devrim"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Rowan Univ, Sch Med Engn Sci & Hlth, Camden, NJ 08103 USA", 
      "name": "Miri, Amir K."
    }
  ], 
  "datePublished": "2021-01-01", 
  "description": "Microfluidic tumors-on-chips models have revolutionized anticancer therapeutic research by creating an ideal microenvironment for cancer cells. The tumor microenvironment (TME) includes various cell types and cancer stem cells (CSCs), which are postulated to regulate the growth, invasion, and migratory behavior of tumor cells. In this review, the biological niches of the TME and cancer cell behavior focusing on the behavior of CSCs are summarized. Conventional cancer models such as 3D cultures and organoid models are reviewed. Opportunities for the incorporation of CSCs with tumors-on-chips are then discussed for creating tumor invasion models. Such models will represent a paradigm shift in the cancer community by allowing oncologists and clinicians to predict better which cancer patients will benefit from chemotherapy treatments.", 
  "headline": "Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions", 
  "identifier": 230310, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Cancer Stem Cells in Tumor Modeling: Challenges and Future Directions", 
  "url": "https://aperta.ulakbim.gov.tr/record/230310"
}