1 Ocak 2022 Dergi makalesi Açık Erişim

Taheri, Serpil; Karaca, Zuleyha; Rassoulzadegan, Minoo; Mehmetbeyoglu, Ecmel; Zararsiz, Gokmen; Sener, Elif Funda; Bayram, Kezban Korkmaz; Tufan, Esra; Sahin, Mustafa Caglar; Marasli, Mert Kahraman; Memis, Mehmet; Canatan, Halit; Ozturk, Figen; Tanriverdi, Fatih; Unluhizarci, Kursad; Kelestimur, Fahrettin

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Karaca, Zuleyha</subfield>
    <subfield code="u">Erciyes Univ, Dept Endocrinol, Med Sch, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Rassoulzadegan, Minoo</subfield>
    <subfield code="u">Univ Cote Azur, INSERM, CNRS, Nice, France</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Mehmetbeyoglu, Ecmel</subfield>
    <subfield code="u">Cardiff Univ, Dept Canc &amp; Genet, Cardiff, Wales</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Zararsiz, Gokmen</subfield>
    <subfield code="u">Erciyes Univ Med Sch, Dept Biostat, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Sener, Elif Funda</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Bayram, Kezban Korkmaz</subfield>
    <subfield code="u">Erciyes Univ, Betul Ziya Eren Genome &amp; Stem Cell Ctr, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Tufan, Esra</subfield>
    <subfield code="u">Erciyes Univ, Betul Ziya Eren Genome &amp; Stem Cell Ctr, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Sahin, Mustafa Caglar</subfield>
    <subfield code="u">Erciyes Univ, Betul Ziya Eren Genome &amp; Stem Cell Ctr, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Marasli, Mert Kahraman</subfield>
    <subfield code="u">Erciyes Univ, Betul Ziya Eren Genome &amp; Stem Cell Ctr, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Memis, Mehmet</subfield>
    <subfield code="u">Erciyes Univ, Betul Ziya Eren Genome &amp; Stem Cell Ctr, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Canatan, Halit</subfield>
    <subfield code="u">Erciyes Univ Med Sch, Dept Med Biol, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Ozturk, Figen</subfield>
    <subfield code="u">Erciyes Univ, Dept Pathol, Med Sch, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Tanriverdi, Fatih</subfield>
    <subfield code="u">Erciyes Univ, Dept Endocrinol, Med Sch, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Unluhizarci, Kursad</subfield>
    <subfield code="u">Erciyes Univ, Dept Endocrinol, Med Sch, Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Kelestimur, Fahrettin</subfield>
    <subfield code="u">Yeditepe Univ, Dept Endocrinol, Med Sch, Istanbul, Turkey</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">CELLULAR AND MOLECULAR NEUROBIOLOGY</subfield>
    <subfield code="v">42</subfield>
    <subfield code="n">5</subfield>
    <subfield code="c">1523-1542</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1007/s10571-021-01043-0</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">The Characterization of Sex Differences in Hypoglycemia-Induced Activation of HPA Axis on the Transcriptomic Level</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Taheri, Serpil</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:aperta.ulakbim.gov.tr:230278</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2022-01-01</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/230278/files/bib-8063bad7-ca6a-4b36-b406-7117f6a9e146.txt</subfield>
    <subfield code="z">md5:2d1a5bdf2c122d1d839e4bd6c443c8bf</subfield>
    <subfield code="s">398</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <controlfield tag="005">20221007075022.0</controlfield>
  <controlfield tag="001">230278</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">Activation of the hypothalamic-pituitary-adrenal (HPA) axis using an insulin tolerance test (ITT) is a medical diagnostic procedure that is frequently used in humans to assess the HPA and growth-hormone (GH) axes. Whether sex differences exist in the response to ITT stress is unknown. Thus, investigations into the analysis of transcripts during activation of the HPA axis in response to hypoglycemia have revealed the underlying influences of sex in signaling pathways that stimulate the HPA axis. We assessed four time points of ITT application in Balb/c mice. After insulin injection, expression levels of 192 microRNAs and 41 mRNAs associated with the HPA, GH and hypothalamic-pituitary-gonadal (HPG) axes were determined by real-time RT-PCR in the hypothalamus, pituitary and adrenal tissues, as well as blood samples (Raw data accession:). Although the ITT is commonly used as a gold standard for evaluating the HPA axis, we found completely different responses between males and females with respect to activation of the HPA axis. While activation of several transcripts in the hypothalamus and pituitary was observed after performing the ITT in males within 10 min, females responded via the pituitary and adrenal immediately and durably over 40 min. Additionally, we found that microRNA alterations precede mRNA responses in the HPA axis. Furthermore, robust changes in the levels of several transcripts including Avpr1b and Avpr2 observed at all time points strongly suggest that transcriptional control of these genes occurs mostly via differential signaling in pituitary and blood between males and females. Male and female HPA axis responses to ITT involve a number of sophisticated regulatory signaling pathways of miRNAs and mRNAs. Our results highlight the first robust markers in several layers of HPA, HPG and GH axis involved in ITT/hypoglycemia stress-induced dynamics.</subfield>
  </datafield>
</record>